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Analytes were confirmed by ultra\u2010performance liquid chromatography\u2013mass spectrometry (UPLC\u2010MS(n)) analysis of human biospecimens from dietary intervention studies of (poly)phenol\u2010rich diets. One hundred and sixty six verified compounds were subsequently analyzed on an untargeted metabolomics platform to acquire chromatographic and high\u2010resolution mass spectral data for construction of a DEL. The DEL facilitated identification\/annotation of 123 metabolites associate with exposure to (poly)phenol enriched diets, which included aromatic ketones, benzoic acids, ellagic acids, caffeoylquinic acids, catecholamines, coumarins, hippuric acid, hydroxytoluenes, phenylamines, stilbenes, urolithins, valerolactones, and xanthonoids, in untargeted metabolomics datasets acquire from human plasma and urine reference materials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The DEL focusing on (poly)phenols and their metabolites of dietary exposure facilitated identification\/annotation of ingested food components and their associated pathways in untargeted metabolomics datasets acquired from human biospecimens. The DEL continues to expand with the aim to provide evidence\u2010based data for dietary metabolites in exposome research and inform the development of dietary intervention strategies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202100922","type":"journal-article","created":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T08:14:12Z","timestamp":1643789652000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Exploring the Contribution of (Poly)phenols to the Dietary Exposome Using High Resolution Mass Spectrometry Untargeted Metabolomics"],"prefix":"10.1002","volume":"66","author":[{"given":"Yuan\u2010Yuan","family":"Li","sequence":"first","affiliation":[{"name":"Nutrition Research Institute UNC Chapel Hill  500 Laureate Way Kannapolis NC 28081 USA"},{"name":"North Carolina Human Health Exposure Analysis Resource (NC HHEAR) Hub  NC 28081 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blake","family":"Rushing","sequence":"additional","affiliation":[{"name":"Nutrition Research Institute UNC Chapel Hill  500 Laureate Way Kannapolis NC 28081 USA"},{"name":"North Carolina Human Health Exposure Analysis Resource (NC HHEAR) Hub  NC 28081 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madison","family":"Schroder","sequence":"additional","affiliation":[{"name":"Nutrition Research Institute UNC Chapel Hill  500 Laureate Way Kannapolis NC 28081 USA"},{"name":"North Carolina Human Health Exposure Analysis Resource (NC HHEAR) Hub  NC 28081 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Sumner","sequence":"additional","affiliation":[{"name":"Nutrition Research Institute UNC Chapel Hill  500 Laureate Way Kannapolis NC 28081 USA"},{"name":"North Carolina Human Health Exposure Analysis Resource (NC HHEAR) Hub  NC 28081 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7290-4496","authenticated-orcid":false,"given":"Colin D.","family":"Kay","sequence":"additional","affiliation":[{"name":"North Carolina Human Health Exposure Analysis Resource (NC HHEAR) Hub  NC 28081 USA"},{"name":"Food Bioprocessing and Nutrition Sciences Department Plants for Human Health Institute North Carolina State University  Kannapolis NC 28081 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,25]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1516878112"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jada.2004.08.001"},{"key":"e_1_2_9_3_1","unstructured":"USDA U.S. Department of Agriculture Agricultural Research Service.2011."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8FO01997E"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1254766"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200800516"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40495-019-00196-3"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-020-05268-4"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-323071"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1541-4337.12351"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12676"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2020.02.008"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.4465"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2010.08.018"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8FO01019F"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqy380"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.112.049247"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12676"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.115.125690"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10111718"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2020.00121"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.7b00196"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.114.104364"},{"key":"e_1_2_9_24_1","unstructured":"S.Bowman J.Clemens J.Friday N.Schroeder M.Shimizu R.LaComb A.MoshfeghFood Patterns Equivalents Intakes by Americans: What We Eat in America NHANES 2003\u20102004 and 2015\u20102016. 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