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Thus, GLP\u20101 analogs are approved for the treatment of obesity, yet cost and side effects limit their use. L\u2010cells are mainly localized in the distal ileum and colon, which hinders the utilization of nutrients targeting GLP\u20101 secretion. This study proposes a controlled delivery system for nutrients, inducing a prolonged endogenous GLP\u20101 release which results in a decrease food intake.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>\u03b1\u2010Linolenic acid (\u03b1LA) was loaded into thermally hydrocarbonized porous silicon (THCPSi) particles. In vitro characterization and in vivo effects of \u03b1LA loaded particles on GLP\u20101 secretion and food intake were studied in mice. A total of 40.4\u00a0\u00b1 3.2% of loaded \u03b1LA is released from particles into biorelevant buffer over 24 h, and \u03b1LA loaded THCPSi significantly increased in vitro GLP\u20101 secretion. Single\u2010dose orally given \u03b1LA loaded mesoporous particles increased plasma active GLP\u20101 levels at 3 and 4 h and significantly reduced the area under the curve of 24 h food intake in mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>\u03b1LA loaded THCPSi particles could be used to endogenously stimulate sustain gastrointestinal hormone release and reduce food intake.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202100978","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T11:51:43Z","timestamp":1639050703000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Colonic Delivery of \u03b1\u2010Linolenic Acid by an Advanced Nutrient Delivery System Prolongs Glucagon\u2010Like Peptide\u20101 Secretion and Inhibits Food Intake in Mice"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9615-1054","authenticated-orcid":false,"given":"Remi","family":"Kamakura","sequence":"first","affiliation":[{"name":"Research Unit of Biomedicine Faculty of Medicine University of Oulu  Oulu FI\u201090220 Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghulam Shere","family":"Raza","sequence":"additional","affiliation":[{"name":"Research Unit of Biomedicine Faculty of Medicine University of Oulu  Oulu FI\u201090220 Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ermei","family":"M\u00e4kil\u00e4","sequence":"additional","affiliation":[{"name":"Department of Physics and Astronomy University of Turku  Turku FI\u201020014 Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joakim","family":"Riikonen","sequence":"additional","affiliation":[{"name":"Department of Applied Physics Faculty of Science and Forestry University of Eastern Finland  Kuopio FI\u201070211 Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miia","family":"Kovalainen","sequence":"additional","affiliation":[{"name":"Research Unit of Biomedicine Faculty of Medicine University of Oulu  Oulu FI\u201090220 Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Ueta","sequence":"additional","affiliation":[{"name":"Department of Physiology School of Medicine University of Occupational and Environmental Health  Kitakyushu 807\u20138555 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vesa\u2010Pekka","family":"Lehto","sequence":"additional","affiliation":[{"name":"Department of Applied Physics Faculty of Science and Forestry University of Eastern Finland  Kuopio FI\u201070211 Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarno","family":"Salonen","sequence":"additional","affiliation":[{"name":"Department of Physics and Astronomy University of Turku  Turku FI\u201020014 Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4460-2604","authenticated-orcid":false,"given":"Karl\u2010Heinz","family":"Herzig","sequence":"additional","affiliation":[{"name":"Research Unit of Biomedicine Faculty of Medicine University of Oulu  Oulu FI\u201090220 Finland"},{"name":"Department of Pediatric Gastroenterology and Metabolic Diseases Pediatric Institute Poznan University of Medical Sciences  Pozna\u0144 60\u2013572 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,19]]},"reference":[{"key":"e_1_2_9_1_1","unstructured":"WHO Obesity and overweight https:\/\/www.who.int\/en\/news-room\/fact-sheets\/detail\/obesity-and-overweight(accessed: October 2021)."},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2007.10.008"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00034.2006"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3070"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.01.004"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2019.09.010"},{"key":"e_1_2_9_7_1","first-page":"390","volume":"14","author":"Andersen A.","year":"2018","journal-title":"Nat. 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