{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:51:13Z","timestamp":1786978273954,"version":"build-2736575974"},"reference-count":65,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T00:00:00Z","timestamp":1644537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["109\u20102320\u2010B\u2010002 \u2010012 \u2010MY3"],"award-info":[{"award-number":["109\u20102320\u2010B\u2010002 \u2010012 \u2010MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["110\u20102320\u2010B\u2010002 \u2010019 \u2010MY3"],"award-info":[{"award-number":["110\u20102320\u2010B\u2010002 \u2010019 \u2010MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec>\n                    <jats:title>Scope<\/jats:title>\n                    <jats:p>\n                      <jats:italic>S<\/jats:italic>\n                      \u2010Allylcysteine (SAC) is the most abundant organosulfur molecule derived from aged garlic. The effects ofSAC on improving Aging in naturally aged C57BL\/6J male mice and mitochondrial dynamics in\n                      <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                      and its underlying mechanisms is evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>\n                      When mice have attained reproductive senescence at 60 weeks of age, SAC is supplemented to 0.05% and 0.2% into their normal diet for 12 weeks. The results show that SAC could significantly improve the level of hepatic optic atrophy 1 (\n                      <jats:italic>OPA1<\/jats:italic>\n                      ) mRNA, which is a key factor for mitochondrial fusion, and consequently elevated the mitochondrial biogenesis\u2010related proteins sirtuin 1 (SIRT1) and peroxisome proliferator\u2010activated receptor\u2010gamma coactivator\u20101 alpha (PGC\u20101\u03b1), thus ameliorating oxidative stress, such as malondialdehyde (MDA) in the liver and 8\u2010hydroxy\u20102'\u2010deoxyguanosine (8\u2010OHdG) in urine. Among the biochemical markers of aging, SAC significantly reduces liver galactosidase \u03b21 (GLB1) and senescence\u2010associated \u03b2\u2010galactosidase (SA\u2010\u03b2gal), which are induced by replicative senescence. The mitochondria with green fluorescent protein (GFP)\u2010tagged transgenic strain SJ4103\n                      <jats:italic>C. elegans<\/jats:italic>\n                      is incubated with 5 or 50\u00a0\u00b5M SAC, and SAC treated groups maintain the linear morphology of mitochondria.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SAC regulates mitochondrial dynamics and ameliorated aging to a significant degree. This study also confirms that mitochondrial dynamics are a promising target for screening materials to combat aging and as a direction for anti\u2010aging product development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mnfr.202101077","type":"journal-article","created":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T10:44:35Z","timestamp":1643453075000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["<i>S<\/i>\n                    \u2010Allylcysteine Ameliorates Aging Features via Regulating Mitochondrial Dynamics in Naturally Aged C57BL\/6J Mice"],"prefix":"10.1002","volume":"66","author":[{"given":"Pin\u2010Hua","family":"Chen","sequence":"first","affiliation":[{"name":"Institute of Food Sciences and Technology National Taiwan University  Taipei 10617 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Han","family":"Chang","sequence":"additional","affiliation":[{"name":"Institute of Food Sciences and Technology National Taiwan University  Taipei 10617 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Sheng","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Food Sciences and Technology National Taiwan University  Taipei 10617 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9470-4110","authenticated-orcid":false,"given":"Kalyanam","family":"Nagabhushanam","sequence":"additional","affiliation":[{"name":"Sabinsa Corporation  20 Lake Drive, East Windsor NJ 08520 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi\u2010Tang","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Food Science Rutgers University  New Brunswick NJ 08901 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5188-7030","authenticated-orcid":false,"given":"Min\u2010Hsiung","family":"Pan","sequence":"additional","affiliation":[{"name":"Institute of Food Sciences and Technology National Taiwan University  Taipei 10617 Taiwan"},{"name":"Department of Medical Research China Medical University Hospital China Medical University  Taichung 40402 Taiwan"},{"name":"Department of Health and Nutrition Biotechnology Asia University  Taichung 41354 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,11]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2007.07.011"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/907162"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.114.201749"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12986"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf0106648"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2004.03.001"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2012.03.024"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/gnv130"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.05.039"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10053"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00861"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.00009"},{"key":"e_1_2_9_13_1","first-page":"377","volume":"2","author":"Fusco D.","year":"2007","journal-title":"Clin. 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