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This study aims to investigate the preventive effects of sesamol, a functional component from sesame, on suppressing TPC production, and on the deep\u2010frying oil (DFO)\u2010induced liver lipid metabolism disorders and gut homeostasis disruption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Sesamol addition (0.2\u00a0mg\u00a0mL<jats:sup>\u22121<\/jats:sup>) improves the quality of the soybean oil by reducing the production of TPC during the deep\u2010frying process (180\u00a0\u00b0C for 40\u00a0h). The diet\u2010induced obesity model is established by feeding mice with a high\u2010fat diet for 8 weeks. Either sesamol pre\u2010treated DFO or sesamol supplementation (0.2%, w\/w) in the diet reduces the liver lipid accumulation in the obese mice by increasing lipolysis\u2010related genes expression. Sesamol elevates the antioxidant enzyme activities, protectes the integrity of the jejunum and colon barrier, and enhances the relative abundance of <jats:italic>Bifidobacterium<\/jats:italic> and <jats:italic>Akkermansia<\/jats:italic> in obese mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sesamol suppresses TPC production and prolongs the use time of deep\u2010frying oil. Meanwhile, sesamol can improve TPC\u2010induced liver lipid metabolism disorders and gut dysbiosis, thus reducing the health risks associated with deep\u2010fried food.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202101122","type":"journal-article","created":{"date-parts":[[2022,2,20]],"date-time":"2022-02-20T07:35:03Z","timestamp":1645342503000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Preventive Effects of Sesamol on Deep\u2010Frying Oil\u2010Induced Liver Metabolism Disorders by Altering Gut Microbiota and Protecting Gut Barrier Integrity"],"prefix":"10.1002","volume":"66","author":[{"given":"Lei","family":"Wang","sequence":"first","affiliation":[{"name":"College of Food Science and Engineering Northwest A&amp;F University  Yangling 712100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixuan","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Food Science 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