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The major anthocyanins in human diets are glycosides of cyanidin and delphinidin, and structure can influence both absorption and bioactivity. The aim of this study is to determine the effects of two major types of anthocyanins on low\u2010density lipoprotein cholesterol and other cardiometabolic markers for cardiovascular disease (CVD) risk in hyperlipidemic individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Fifty\u2010two hyperlipidemic participants complete this randomized, placebo\u2010controlled, double\u2010blind, three arm crossover trial. Participants ingest capsules containing 320\u00a0mg of anthocyanins (bilberry trihydroxy\u2010type or black rice dihydroxy\u2010type) or placebo once daily for 28 days. Biomarkers of CVD risk are measured before and after the intervention period. Compared to the placebo, neither anthocyanin treatment significantly (<jats:italic>p<\/jats:italic> &lt; 0.05) changes circulating levels of lipoproteins (total\u2010\/high\u2010density lipoprotein (HDL)\u2010\/low\u2010density lipoprotein (LDL)\u2010cholesterol, triglycerides, Apolipoprotein B (ApoB)), biomarkers of glycemic control (fasting glucose, fructosamine), biomarkers of HDL function (ApoA1, HDL3, paraoxonase\u20101 (PON1) arylesterase, and lactonase activities), or plasma bile acids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These data do not support the notion that regular consumption of anthocyanins beneficially affects glycemic control or lipoprotein profiles or functions. It is possible the no effect observation is due to the relatively short duration of treatments.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202101157","type":"journal-article","created":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T12:08:03Z","timestamp":1649246883000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["No Effect of Isolated Anthocyanins from Bilberry Fruit and Black Rice on LDL Cholesterol or other Biomarkers of Cardiovascular Disease in Adults with Elevated Cholesterol: A Randomized, Placebo\u2010Controlled, Cross\u2010Over Trial"],"prefix":"10.1002","volume":"66","author":[{"given":"Hassan","family":"Aboufarrag","sequence":"first","affiliation":[{"name":"Quadram Institute Bioscience Norwich Research Park  Norwich NR4 7UQ UK"},{"name":"Food Science and Technology Department Faculty of Agriculture Alexandria University  Alexandria 23511 Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5925-9170","authenticated-orcid":false,"given":"Wendy J.","family":"Hollands","sequence":"additional","affiliation":[{"name":"Quadram Institute Bioscience Norwich Research Park  Norwich NR4 7UQ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine","family":"Percival","sequence":"additional","affiliation":[{"name":"Quadram Institute Bioscience Norwich Research Park  Norwich NR4 7UQ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Philo","sequence":"additional","affiliation":[{"name":"Quadram Institute Bioscience Norwich Research Park  Norwich NR4 7UQ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George M.","family":"Savva","sequence":"additional","affiliation":[{"name":"Quadram Institute Bioscience Norwich Research Park  Norwich NR4 7UQ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9805-6947","authenticated-orcid":false,"given":"Paul A.","family":"Kroon","sequence":"additional","affiliation":[{"name":"Quadram Institute Bioscience Norwich Research Park  Norwich NR4 7UQ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gheart.2018.09.511"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx144"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP161445.RA"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.8.6.737"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.85.4.1279"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.79.1.8"},{"key":"e_1_2_9_8_1","first-page":"212525","volume":"7","author":"Kosmas C. 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