{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T02:38:38Z","timestamp":1789180718893,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T00:00:00Z","timestamp":1658793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>To compare the effects of three high\u2010fat diets (HFDs) based on coconut, sunflower, or extra virgin olive oils (EVOOs) on adipose tissue, metabolism, and inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Mice are fed for 16\u00a0weeks on their respective HFD. HFD based on coconut oil produces significantly lower body weight than EVOO\u2010 or sunflower oil\u2010based HFDs. Furthermore, the coconut oil HFD leads to metabolic disturbances such as reduction of circulating leptin and adiponectin concentrations, hypertriglyceridemia, hepatomegaly, and liver triglyceride accumulation. Likewise, this diet produces an increase in serum pro\u2010inflammatory cytokines (interleukin 6 [IL\u20106] and tumor necrosis factor\u2010\u03b1 [TNF\u2010\u03b1]). In white (WAT) and brown (BAT) adipose tissue, the HFD based on coconut oil does not cause significant changes in the expression of studied proteins related to thermogenesis (uncoupling protein 1 [UCP\u20101]), mitochondrial biogenesis, and browning (peroxisome proliferator\u2010activated receptor\u2010\u03b3 coactivator 1\u03b1 [PGC\u20101\u03b1] and nuclear factor E2\u2010related factor 2 [Nrf2]). However, the HFD based on EVOO induces upregulation of UCP\u20101, PGC\u20101\u03b1, and Nrf2 expression in BAT, increases the expression of UCP\u20101 and PGC\u20101\u03b1 in inguinal WAT, and enhances the expression of PGC\u20101\u03b1 in epididymal WAT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>An HFD based on coconut oil could reduce circulating leptin and adiponectin concentrations, increase the liver fat content, raise serum triglycerides, and promote inflammation by increasing circulating pro\u2010inflammatory cytokines, while an EVOO\u2010based HFD could increase thermogenic activity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202200082","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T09:08:17Z","timestamp":1658135297000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Differential Immunometabolic Effects of High\u2010Fat Diets Containing Coconut, Sunflower, and Extra Virgin Olive Oils in Female Mice"],"prefix":"10.1002","volume":"66","author":[{"given":"Carmen","family":"Rodr\u00edguez\u2010Garc\u00eda","sequence":"first","affiliation":[{"name":"Department of Health Sciences, Faculty of Experimental Sciences University of Ja\u00e9n  Ja\u00e9n 23071 Spain"},{"name":"University Institute of Research in Olive Groves and Olive Oils University of Jaen  Campus las Lagunillas, s\/n Ja\u00e9n 23071 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"S\u00e1nchez\u2010Quesada","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Faculty of Experimental Sciences University of Ja\u00e9n  Ja\u00e9n 23071 Spain"},{"name":"University Institute of Research in Olive Groves and Olive Oils University of Jaen  Campus las Lagunillas, s\/n Ja\u00e9n 23071 Spain"},{"name":"Agri\u2010food Campus of International Excellence (ceiA3)  C\u00f3rdoba 14071 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