{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T07:25:34Z","timestamp":1781249134372,"version":"3.54.1"},"reference-count":43,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T00:00:00Z","timestamp":1656115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Sweet potato (<jats:italic>Ipomoea batatas<\/jats:italic> L.) is one of the leading crops worldwide, containing high nutritional components such as fiber and polyphenols. Root tuber of Simon 1 (SIMON), a cultivar of sweet potato, is a folk food in China with a hemostasis function but lacking experimental data support.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Now the protective effect of SIMON on chemotherapy\u2010induced thrombocytopenia (CIT), a serious complication of cancer treatment, is investigated for the first time by a CIT mouse model induced by intraperitoneal injection of carboplatin. As a result, SIMON raises the number of peripheral platelets, white blood cells, and bone marrow nucleated cells in CIT mice significantly. Besides, carboplatin\u2010induced atrophy of the thymus, spleen, and disordered metabolism of the inflammatory immune system and glycerophospholipids are also reversed by SIMON. Phytochemical analysis of SIMON indicates 16 compounds including eight phenolic derivatives, which might be associated with its anti\u2010CIT bioactivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sweet potato (SIMON) may be an efficient function food in the prevention of bleeding disorders.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202200126","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T07:18:50Z","timestamp":1655450330000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Protective Effect of Sweet Potato Root Tuber on Chemotherapy\u2010Induced Thrombocytopenia"],"prefix":"10.1002","volume":"66","author":[{"given":"Zi\u2010Heng","family":"Qi","sequence":"first","affiliation":[{"name":"Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of Education Yunnan Provincial Center for Research &amp; Development of Natural Products School of Chemical Science and Technology Yunnan University  Kunming 650091 P. 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