{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:28:09Z","timestamp":1787668089470,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T00:00:00Z","timestamp":1687392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K11580"],"award-info":[{"award-number":["20K11580"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>High\u2010fat diet (HFD) intake induces gut dysbiosis, inflammation in the peripheral tissues, and a reduction in immunoglobulin A (IgA) coating of gut bacteria, which is related to HFD\u2010induced insulin resistance (IR). This study evaluates the effect of cyclic nigerosylnigerose (CNN), a dietary fiber that prevents gut inflammation and promotes IgA coating of gut bacteria, on the above\u2010mentioned HFD\u2010induced disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Balb\/c mice are fed an HFD and administered CNN for 20\u00a0weeks. CNN administration reduces mesenteric adipose tissue weight, colonic tumor necrosis factor \u03b1 (TNF\u03b1) mRNA expression, and serum endotoxin levels and ameliorates HFD\u2010induced abnormal glucose metabolism. Additionally, CNN administration promotes gut bacteria\u2010specific IgA secretion and alters IgA reactivity to gut bacteria. The alterations of IgA reactivity to specific bacteria such as <jats:italic>Erysipelatoclostridium<\/jats:italic>, <jats:italic>Escherichia<\/jats:italic>, <jats:italic>Faecalibaculum<\/jats:italic>, Lachnospiraceae genera, and <jats:italic>Stenotrophomonas<\/jats:italic> are correlated with mesenteric adipose tissue weight, colonic TNF\u03b1 mRNA expression, serum endotoxin levels, and a homeostasis model assessment for IR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CNN\u2010induced alterations in IgA reactivity to gut bacteria may be related to the suppression of HFD\u2010induced fat deposition, colonic inflammation, endotoxemia, and IR. These observations indicate that dietary fiber that modulates IgA reactivity to gut bacteria may be useful in preventing HFD\u2010induced disorders.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202200389","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T12:53:06Z","timestamp":1682081586000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cyclic Nigerosylnigerose Attenuates High\u2010Fat Diet\u2010Induced Fat Deposition, Colonic Inflammation, and Abnormal Glucose Metabolism and Modifies Gut Immunoglobulin a Reactivity to Commensal Bacteria"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0990-4615","authenticated-orcid":false,"given":"Takeshi","family":"Tsuruta","sequence":"first","affiliation":[{"name":"Graduate School of Environmental and Life Science Okayama University  Okayama 700\u20108530 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Sonoyama","sequence":"additional","affiliation":[{"name":"Research Faculty of Agriculture Hokkaido University  Sapporo 060\u20108589 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taisei","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Graduate School of Environmental and Life Science Okayama University  Okayama 700\u20108530 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qui D.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Graduate School of Environmental and Life Science Okayama University  Okayama 700\u20108530 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Mizote","sequence":"additional","affiliation":[{"name":"Hayashibara Co., Ltd.  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