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Amylin, a pancreatic \u03b2\u2010cell hormone co\u2010secreted with insulin, participates in the central regulation of satiation, but also forms pancreatic amyloid in persons with type\u20102 diabetes and synergistically interacts with brain amyloid \u03b2 (A\u03b2) pathology, in both sporadic and familial Alzheimer's disease (AD). Growing evidence from studies of tumor growth, together with early observations in skeletal muscle, indicates amylin as a potential trigger of cellular metabolic reprogramming. Because the blood, cerebrospinal fluid, and brain parenchyma in humans with AD have increased concentrations of amylin, amylin\u2010mediated pathological processes in the brain may involve neuronal metabolic remodeling. This review summarizes recent progress in understanding the link between prediabetic hypersecretion of amylin and risk of neuronal metabolic remodeling and AD and suggests nutritional and medical effects of food constituents that might prevent and\/or ameliorate amylin\u2010mediated neuronal metabolic remodeling.<\/jats:p>","DOI":"10.1002\/mnfr.202200405","type":"journal-article","created":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T09:49:33Z","timestamp":1674899373000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Type\u20102 Diabetes, Pancreatic Amylin, and Neuronal Metabolic Remodeling in Alzheimer's Disease"],"prefix":"10.1002","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7737-0382","authenticated-orcid":false,"given":"Noah","family":"Leibold","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Nutritional Sciences The University of Kentucky  Lexington KY 40506 USA"},{"name":"The Research Center for Healthy Metabolism The University of Kentucky  Lexington KY 40506 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Bain","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Metabolism, and Nutrition Department of Medicine Claude D. 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