{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:52:31Z","timestamp":1788306751942,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T00:00:00Z","timestamp":1670198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Ulcerative colitis (UC) is a common chronic recurrent inflammatory bowel disease. This study attempts to reveal the improvement mechanism of floral mushroom polysaccharide (FMPS) on UC from the perspective of coordinated interaction between intestinal microbes and intestinal helper T cell 17 (Th17)\/regulatory T cell (Treg) balance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Dextran sulfate sodium (DSS)\u2010induced colitis mice model is used for the experiment. The results suggest that FMPS up\u2010regulated the expression of occludin, ZO\u20101, and MUC2, and down\u2010regulated the secretion of TNF\u2010\u03b1, IL\u20101\u03b2, and IL\u20106 in colitis mice. Importantly, FMPS restores intestinal Th17\/Treg balance. Meanwhile, FMPS can regulate intestinal microorganisms and improve the level of short\u2010chain fatty acids (SCFAs) in colitis mice. Intestinal microbial depletion and fecal microbiota transplantation (FMT) experiments reveal that FMPS ameliorated UC is mediated by intestinal microbiome. Flow cytometry further proves that FMPS restores intestinal Th17\/Treg balance in a microbial\u2010dependent manner.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results indicate that FMPS has the potential to improve UC, and its mechanism depends on the restoration of Th17\/Treg balance mediated by intestinal microorganisms. Therefore, it is suggested that FMPS dietary supplement can be potentially used to intervene UC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202200408","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T12:47:33Z","timestamp":1669294053000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Huangshan Floral Mushroom Polysaccharide Ameliorates Dextran Sulfate Sodium\u2010Induced Colitis in Mice by Modulating Th17\/Treg Balance in a Gut Microbiota\u2010Dependent Manner"],"prefix":"10.1002","volume":"67","author":[{"given":"Ming\u2010yue","family":"Zou","sequence":"first","affiliation":[{"name":"Engineering Research Center of Bio\u2010process Ministry of Education Hefei University of Technology  Hefei 230009 China"},{"name":"School of Food and Biological Engineering Hefei University of Technology  Hefei 230009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0251-1923","authenticated-orcid":false,"given":"Yu\u2010jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Bio\u2010process Ministry of Education Hefei University of Technology  Hefei 230009 China"},{"name":"School of Food and Biological Engineering Hefei University of Technology  Hefei 230009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Food and Biological Engineering Hefei University of Technology  Hefei 230009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan\u2010qiang","family":"Xiong","sequence":"additional","affiliation":[{"name":"School of Food and Biological Engineering Hefei University of Technology  Hefei 230009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Sericultural Research Institute Anhui Academy of Agricultural Sciences  Hefei 230061 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2010hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Bio\u2010process Ministry of Education Hefei University of Technology  Hefei 230009 China"},{"name":"School of Food and Biological Engineering Hefei University of Technology  Hefei 230009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,5]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.01.028"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-0992-y"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i1.5"},{"key":"e_1_2_9_4_1","first-page":"108","volume":"13","author":"McGilligan V. 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