{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T19:17:17Z","timestamp":1789067837333,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T00:00:00Z","timestamp":1666224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2020M683206"],"award-info":[{"award-number":["2020M683206"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Non\u2010alcoholic fatty liver disease (NAFLD) is a type of metabolic syndrome characterized of abnormal lipid deposition in the liver. Adlay polyphenol (AP), an effective component extracted from <jats:italic>Coix lacryma\u2010jobi<\/jats:italic> L., has been reported that it can be used as a dietary supplement to prevent NAFLD. In this study, the mechanism and action of AP on lipid metabolism and regulation of intestinal flora are investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>AP significantly decreases the lipid accumulation in free fatty acid\u2010treated HepG2 cells. Western blot results indicate that AP improves lipid metabolism via activating the p\u2010AMPK\/p\u2010ACC pathway. In vivo experiments show AP treatment significantly decreases the body weight, liver weight, hepatic triglyceride, and total cholesterol contents, as well as the serum glucose levels in high fat diet\u2010fed mice, which may affect lipid accumulation by activating AMPK pathway and changing intestinal bacterial communities and intestinal microbiome metabolism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>AP can be used as a food supplement for improving lipid metabolic dysfunction and reducing the incidence of metabolic diseases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202200447","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T13:17:25Z","timestamp":1665407845000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Adlay (<i>Coix lacryma\u2010jobi<\/i> L.) Polyphenol Improves Hepatic Glucose and Lipid Homeostasis through Regulating Intestinal Flora via AMPK Pathway"],"prefix":"10.1002","volume":"66","author":[{"given":"Shengsuo","family":"Ma","sequence":"first","affiliation":[{"name":"School of Traditional Chinese Medicine Jinan University  Guangzhou Guangdong 510632 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine Jinan University  Guangzhou Guangdong 510632 China"},{"name":"Department of Traditional Chinese Medicine Yuebei People's Hospital  Shaoguan Guangdong 512026 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yucong","family":"Shi","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine Jinan University  Guangzhou Guangdong 510632 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Du","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine Jinan University  Guangzhou Guangdong 510632 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwen","family":"Lv","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine Jinan University  Guangzhou Guangdong 510632 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiarong","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine Jinan University  Guangzhou Guangdong 510632 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enyan","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine Jinan University  Guangzhou Guangdong 510632 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huachong","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine Jinan University  Guangzhou Guangdong 510632 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Deng","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine Jinan University  Guangzhou Guangdong 510632 China"},{"name":"Syndrome of Chinese Medicine The Second Affiliated Hospital of Guangzhou University of Chinese Medicine Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome Guangdong Provincial Key Laboratory of Research on Emergency in CM\u201c \u201dGuangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases AMI Key Lab of Chinese Medicine in Guangzhou Guangzhou Key Laboratory of Chirality Research on Active Components of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0189-7150","authenticated-orcid":false,"given":"Xiao\u2010yin","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine Jinan University  Guangzhou Guangdong 510632 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,20]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.41"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-017-1415-1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i11.1964"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110785"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2017.02.025"},{"key":"e_1_2_9_6_1","first-page":"26","volume":"38","author":"Zhang Y.","year":"2017","journal-title":"Food Sci."},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-019-09786-z"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules17088886"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11030541"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.615858"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-020-00532-0"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21165820"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-021-00614-x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.720726"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.546589"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153496"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21155214"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2020.1719473"},{"key":"e_1_2_9_19_1","first-page":"612","volume":"13","author":"Sacks D.","year":"2018","journal-title":"Int. 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