{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T17:56:53Z","timestamp":1779213413429,"version":"3.51.4"},"reference-count":74,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T00:00:00Z","timestamp":1676505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Lipopolysaccharides and their transporters, LBP and sCD14, are involved in systemic inflammation following a high\u2010fat diet. Natural emulsifiers such as soy lecithin, rich in soybean polar lipids (SPL), are often used by the food industry but little is known about effects of associating SPL with different oils.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Thus, this study investigates the effects of 4 weeks feeding of palm (P) or rapeseed (R) oil\u2010enriched diets with or without SPL in mice, on white adipose tissue (WAT) inflammation, on ileum permeability, and on microbiota composition. When SPL are associated with rapeseed oil, a greater gene expression of leptin and inflammation in WAT is observed compared to P\u2010SPL. In ileum, R\u2010SPL group results in a lower expression of TLR4, IAP that detoxify bacterial LPS and tight junction proteins than R group. In turn, the gene expression of Reg3\u03b2 and Reg3\u03b3, which have antimicrobial activity, is higher in ileum of R\u2010SPL group than in R group. SPL in rapeseed oil increases specific bacterial species belonging to <jats:italic>Lachnospiraceae<\/jats:italic>, <jats:italic>Alistipes<\/jats:italic>, and Bacteroidales.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The incorporation of SPL in a diet with rapeseed oil exerts differential effect on WAT and ileum, with respectively an inflammation of WAT and an antimicrobial activity in ileum, associated with specific microbiota changes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202200461","type":"journal-article","created":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T21:43:26Z","timestamp":1674942206000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Soy Lecithin in High\u2010Fat Diets Exerts Dual Effects on Adipose Tissue Versus Ileum"],"prefix":"10.1002","volume":"67","author":[{"given":"Charline","family":"Buisson","sequence":"first","affiliation":[{"name":"Univ Lyon, CarMeN laboratory INRAE, UMR1397, INSERM, U1060 Universit\u00e9 Claude Bernard Lyon 1  Pierre B\u00e9nite 69310 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentin","family":"Leuzy","sequence":"additional","affiliation":[{"name":"Univ Lyon, CarMeN laboratory INRAE, UMR1397, INSERM, U1060 Universit\u00e9 Claude Bernard Lyon 1  Pierre B\u00e9nite 69310 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuelle","family":"Loizon","sequence":"additional","affiliation":[{"name":"Univ Lyon, CarMeN laboratory INRAE, UMR1397, INSERM, U1060 Universit\u00e9 Claude Bernard Lyon 1  Pierre B\u00e9nite 69310 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuelle","family":"Meugnier","sequence":"additional","affiliation":[{"name":"Univ Lyon, CarMeN laboratory INRAE, UMR1397, INSERM, U1060 Universit\u00e9 Claude Bernard Lyon 1  Pierre B\u00e9nite 69310 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magali","family":"Monnoye","sequence":"additional","affiliation":[{"name":"Micalis Institute Universit\u00e9 Paris\u2010Saclay, INRAE, AgroParisTech  Jouy\u2010en\u2010Josas 78350 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Philippe","sequence":"additional","affiliation":[{"name":"Micalis Institute Universit\u00e9 Paris\u2010Saclay, INRAE, AgroParisTech  Jouy\u2010en\u2010Josas 78350 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"G\u00e9rard","sequence":"additional","affiliation":[{"name":"Micalis Institute Universit\u00e9 Paris\u2010Saclay, INRAE, AgroParisTech  Jouy\u2010en\u2010Josas 78350 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Caroline","family":"Michalski","sequence":"additional","affiliation":[{"name":"Univ Lyon, CarMeN laboratory INRAE, UMR1397, INSERM, U1060 Universit\u00e9 Claude Bernard Lyon 1  Pierre B\u00e9nite 69310 France"},{"name":"CRNH Rh\u00f4ne\u2010Alpes  Oullins 69310 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1859-1032","authenticated-orcid":false,"given":"Fabienne","family":"Laugerette","sequence":"additional","affiliation":[{"name":"Univ Lyon, CarMeN laboratory INRAE, UMR1397, INSERM, U1060 Universit\u00e9 Claude Bernard Lyon 1  Pierre B\u00e9nite 69310 France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,16]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05482"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/83.2.461S"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI27280"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/86.5.1286"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00314.2011"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2009.11.011"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-2518"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00098.2016"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M800156-JLR200"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/170.5.1319"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1391"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-006-0230-1"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/87.5.1219"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/db06-1491"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2017.02.004"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012191"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.11.6164"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00372.2016"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2546"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1220180110"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2015.12.006"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2020.0086"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.06165-11"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/111.1.166"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2019.11.017"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu2020116"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-11-3"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.202001068"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-020-00996-6"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1017\/S000711451000454X"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-7075-7-2"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9010199"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-29971-w"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12020287"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btx791"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1369\/jhc.7A7303.2007"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-398313-8.00006-3"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2003.56"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-013-9214-2"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000163635.62927.34"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/00041433-200312000-00003"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1358\/dnp.2006.19.1.966243"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2012.06.008"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1080\/21623945.2020.1760674"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00029.2015"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114512001213"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2007.10.010"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2015.12.008"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01007009"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2792"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.11.006"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2017.06.023"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29287"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.12.7010-7017.2000"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.33662"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-005-3144-y"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.2.554"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-007-0105-x"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00906"},{"key":"e_1_2_9_60_1","author":"Miao Z.","year":"2022","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9020346"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.07.026"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26093"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1222551"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2021.02.001"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9091881"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-318155"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1209791"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrep.2020.100738"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9FO01760G"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2013.109"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1300318110"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000532"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2019.02.006"}],"container-title":["Molecular Nutrition &amp; Food Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.202200461","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mnfr.202200461","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.202200461","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T15:28:57Z","timestamp":1692631737000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mnfr.202200461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,16]]},"references-count":74,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1002\/mnfr.202200461"],"URL":"https:\/\/doi.org\/10.1002\/mnfr.202200461","archive":["Portico"],"relation":{},"ISSN":["1613-4125","1613-4133"],"issn-type":[{"value":"1613-4125","type":"print"},{"value":"1613-4133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,16]]},"assertion":[{"value":"2022-07-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2200461"}}