{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:53:36Z","timestamp":1790034816706,"version":"4.0.1"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T00:00:00Z","timestamp":1679961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Gamma\u2010aminobutyric acid (GABA) represents positive effects in stress model, but the exact antioxidant remains unclear. This study aims to determine what GABA do and how GABA interfere on oxidative stress in the small intestine of radiation\u2010induced intestinal injury (RIII) mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>C57BL\/6J mice are gavaged. (1) Investigating the effects of GABA (50\u00a0100\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup>\u00a0BW\u00a0d<jats:sup>\u22121<\/jats:sup>) on basic information of healthy mice, and the survival time of RIII mice. (2) Evaluating the effect between GABA and theanine (100\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup>\u00a0BW\u00a0d<jats:sup>\u22121<\/jats:sup>) to RIII mice on the small intestine, by observing jejunum pathology, oxidative stress in small intestine and its mitochondria, and apoptosis protein expression. GABA reduces the weight loss and prolongs the median survival time of RIII mice. GABA and theanine reduce liver hyperemia, protect the villus crypt of jejunum, increase the antioxidant of duodenum and its mitochondria, to maintain the normal function and morphology. Besides, GABA increases B\u2010cell lymphoma\u20102 (Bcl\u20102) expression and inhibits Caspase\u20103 activation, thereby inhibiting mitochondria\u2010induced apoptosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>GABA reduces the oxidative stress of small intestine in RIII mice, and maintains the normal morphology and function of mitochondria, which mechanism is that high Bcl\u20102 expression inhibits the autophagy of mitochondrial pathway, thus reducing intestinal barrier damage.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202200522","type":"journal-article","created":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T07:05:31Z","timestamp":1677654331000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Protection of \u03b3\u2010Amino Butyric Acid on Radiation Induced Intestinal Injury in Mice"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5471-1460","authenticated-orcid":false,"given":"Chenxuan","family":"Ji","sequence":"first","affiliation":[{"name":"School of Public Health Guangdong Pharmaceutical University  Guangzhou 510310 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6357-5918","authenticated-orcid":false,"given":"Ming","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Public Health Guangdong Pharmaceutical University  Guangzhou 510310 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Zou","sequence":"additional","affiliation":[{"name":"School of Food Science Guangdong Pharmaceutical University  Zhongshan 528453 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Fu","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine Guangdong Pharmaceutical University  Guangzhou 510006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhang","family":"Chen","sequence":"additional","affiliation":[{"name":"Infinitus (China) Co. 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