{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:53:35Z","timestamp":1787169215915,"version":"build-2736575974"},"reference-count":68,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFD0502200"],"award-info":[{"award-number":["2017YFD0502200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec>\n                    <jats:title>Scope<\/jats:title>\n                    <jats:p>Aged laying hen\u00a0is recently suggested as a more attractive animal model than rodent for studying nonalcoholic fatty liver disease (NAFLD) of humans. This study aims to reveal effects and metabolic regulation mechanisms of taurine alleviating NAFLD by using the aged laying hen model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Liver histomorphology and biochemical indices show 0.02% taurine effectively alleviated fat deposition and liver damage. Comparative liver lipidomics and gene expressions analyses reveal\u00a0taurine promoted lipolysis, fatty acids oxidation, lipids transport, and reduced oxidative stress in liver. Furthermore, comparative serum metabolomics screen six core metabolites negatively correlated with NAFLD, including linoleic acid, gamma\u2010linolenic acid, pantothenate, L\u2010methionine, 2\u2010methylbutyroylcarnitine, L\u2010carnitine; and two core metabolites positively correlated with NAFLD, including lysophosphatidylcholine (14:0\/0:0) and lysophosphatidylcholine (16:0\/0:0). Metabolic pathway analysis reveals taurine mainly regulated linoleic acid metabolism, cysteine and methionine metabolism, carnitine metabolism, pantothenic acid and coenzyme A biosynthesis metabolism, and glycerophospholipid metabolism to up\u2010adjust levels of six negatively correlated metabolites and down\u2010adjust two positively correlated metabolites for alleviating NAFLD of aged hens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study firstly reveals underlying metabolic mechanisms of taurine alleviating NAFLD using the aged hen model, thereby laying the foundation for taurine's application in the prevention of NAFLD in both human and poultry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mnfr.202200525","type":"journal-article","created":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T08:10:53Z","timestamp":1698826253000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Comparative Lipidomics and Metabolomics\u00a0Reveal the Underlying Mechanisms of Taurine in the Alleviation of Nonalcoholic Fatty Liver Disease Using the Aged Laying Hen Model"],"prefix":"10.1002","volume":"67","author":[{"given":"Zhengwang","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Animal Nutrition and Feed Science College of Animal Sciences &amp; Technology Huazhong Agricultural University  Wuhan 430070 China"},{"name":"Shanghai Yuanyao Agriculture and Animal Husbandry Technology Co., Ltd  Shanghai 200000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manman","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Animal Genetics Breeding and Reproduction College of Animal Sciences &amp; Technology Huazhong Agricultural University  Wuhan 430070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimei","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Animal Nutrition and Feed Science College of Animal Sciences &amp; Technology Huazhong Agricultural University  Wuhan 430070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Animal Nutrition and Feed Science College of Animal Sciences &amp; Technology Huazhong Agricultural University  Wuhan 430070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tieping","family":"Song","sequence":"additional","affiliation":[{"name":"Yichang Tianyou Huamu Technology Co.,Ltd  Yichang 443000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanzhang","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Animal Genetics Breeding and Reproduction College of Animal Sciences &amp; Technology Huazhong Agricultural University  Wuhan 430070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3450-9502","authenticated-orcid":false,"given":"Zhongxin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Animal Nutrition and Feed Science College of Animal Sciences &amp; Technology Huazhong Agricultural University  Wuhan 430070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.109"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S295524"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.849767"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)43138-4"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-128-33022"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920210791110960"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.015"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.116.240358"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2021.117795"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps\/pey596"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3181\/0807-RM-219"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2022.108948"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201800536"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2020.09.044"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41430-021-01010-4"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.13387"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf103167u"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-018-2605-8"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anifeedsci.2019.114339"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2020.104351"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00677.2010"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2016.25"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s44149-021-00001-z"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.06.043"},{"key":"e_1_2_9_25_1","first-page":"835","volume":"18","author":"Masoodi M.","year":"2021","journal-title":"Rev. Gastroenterol. Hepatol."},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.03.004"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2021.110824"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.1c03379"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps.2013-03654"},{"key":"e_1_2_9_30_1","first-page":"2736","volume":"10","author":"EFSA Panel on Additives Products or Substances used in Animal Feed","year":"2012","journal-title":"EFSA J."},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.8b05632"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2013.055"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9FO02882J"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15081992"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M036301"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32511-3"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2020.11.046"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.10.031"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32068"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32066"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01493"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2021.101499"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2022.101870"},{"key":"e_1_2_9_44_1","first-page":"2427","volume":"53","author":"Wang M.","year":"2021","journal-title":"Pak. J. Zool."},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1080\/1828051X.2022.2071774"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2019.10.009"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2020.11.036"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps\/pew160"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps\/pez139"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.892585"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.3382\/japr\/pfz005"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2012.04.036"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2021.104629"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2019.11.018"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.113.003772"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2016.12.001"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.1c02596"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqac150"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/0955-2863(96)00034-4"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps\/pey317"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24183251"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo11010051"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2022.115033"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2021.101320"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2013.11.013"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2013.05.011"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30429"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-021-02738-2"}],"container-title":["Molecular Nutrition &amp; Food Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.202200525","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,30]],"date-time":"2023-12-30T04:46:31Z","timestamp":1703911591000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mnfr.202200525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":68,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1002\/mnfr.202200525"],"URL":"https:\/\/doi.org\/10.1002\/mnfr.202200525","archive":["Portico"],"relation":{},"ISSN":["1613-4125","1613-4133"],"issn-type":[{"value":"1613-4125","type":"print"},{"value":"1613-4133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"2022-08-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2200525"}}