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The current study aims to analyze the antifibrotic effect of ACE oil on the retina of hypertensive mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Mice are rendered hypertensive by administration of NG\u2010nitro\u2010L\u2010arginine\u2010methyl\u2010ester (L\u2010NAME) and simultaneously subjected to dietary supplementation with ACE oil or a reference extra virgin olive oil (EVOO). Intraocular pressure (IOP) is measured by rebound tonometry, and retinal vasculature\/layers are analyzed by fundus fluorescein angiography and optical coherence tomography. Different fibrosis\u2010related parameters are analyzed in the retina and choroid of normotensive and hypertensive mice with or without oil supplementation. Besides preventing the alterations found in hypertensive animals, including increased IOP, reduced fluorescein signal, and altered retinal layer thickness, the ACE oil\u2010enriched diet improves collagen metabolism by regulating the expression of major fibrotic process modulators (matrix metalloproteinases, tissue inhibitors of metalloproteinases, connective tissue growth factor, and transforming growth factor beta family).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Regular consumption of EVOO and ACE oil (with better outcomes in the latter) might help reduce abnormally high IOP values in the context of hypertension\u2010related retinal damage, with significant reduction in the surrounding fibrotic process.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202200623","type":"journal-article","created":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T03:22:37Z","timestamp":1701660157000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Exploring the Potential of Wild Olive (Acebuche) Oil as a Pharm\u2010Food to Prevent Ocular Hypertension and Fibrotic Events in the Retina of Hypertensive Mice"],"prefix":"10.1002","volume":"68","author":[{"given":"\u00c1lvaro","family":"Santana\u2010Garrido","sequence":"first","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Facultad de Farmacia Universidad de Sevilla Sevilla 41012 Spain"},{"name":"Epidemiolog\u00eda Cl\u00ednica y Riesgo Cardiovascular, Instituto de Biomedicina de Sevilla (IBIS) Hospital Universitario Virgen del Roc\u00edo\/Consejo Superior de Investigaciones Cient\u00edficas\/Universidad de Sevilla Sevilla 41013 Spain"},{"name":"Department of Clinical Neuroscience, St. Erik Eye Hospital Karolinska Institutet Stockholm 17177 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Reyes\u2010Goya","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Facultad de Farmacia Universidad de Sevilla Sevilla 41012 Spain"},{"name":"Epidemiolog\u00eda Cl\u00ednica y Riesgo Cardiovascular, Instituto de Biomedicina de Sevilla (IBIS) Hospital Universitario Virgen del Roc\u00edo\/Consejo Superior de Investigaciones Cient\u00edficas\/Universidad de Sevilla Sevilla 41013 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helder","family":"Andr\u00e9","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, St. Erik Eye Hospital Karolinska Institutet Stockholm 17177 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen M.","family":"V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Facultad de Farmacia Universidad de Sevilla Sevilla 41012 Spain"},{"name":"Epidemiolog\u00eda Cl\u00ednica y Riesgo Cardiovascular, Instituto de Biomedicina de Sevilla (IBIS) Hospital Universitario Virgen del Roc\u00edo\/Consejo Superior de Investigaciones Cient\u00edficas\/Universidad de Sevilla Sevilla 41013 Spain"},{"name":"Department of Clinical Neuroscience, St. Erik Eye Hospital Karolinska Institutet Stockholm 17177 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2719-8825","authenticated-orcid":false,"given":"Alfonso","family":"Mate","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Facultad de Farmacia Universidad de Sevilla Sevilla 41012 Spain"},{"name":"Epidemiolog\u00eda Cl\u00ednica y Riesgo Cardiovascular, Instituto de Biomedicina de Sevilla (IBIS) Hospital Universitario Virgen del Roc\u00edo\/Consejo Superior de Investigaciones Cient\u00edficas\/Universidad de Sevilla Sevilla 41013 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,3]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1318"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.313348"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-12-78"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3182944410"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.13553"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10071044"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2018.10.013"},{"key":"e_1_2_9_8_1","first-page":"43","volume":"56","author":"Commission European","year":"2013","journal-title":"Off. 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