{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:50:22Z","timestamp":1786978222321,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T00:00:00Z","timestamp":1699401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec>\n                    <jats:title>Scope<\/jats:title>\n                    <jats:p>Alzheimer's disease is an age\u2010dependent neurodegenerative disorder. Mounting studies focus on the improvement of advanced cognitive impairment by dietary nutrients. Krill oil (KO), a rich source of DHA\/EPA and astaxanthin, is effective in improving cognitive function. The study mainly investigates the protective effects of long\u2010term KO administration on early cognitive impairment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      Results show that 2 months KO administration (50 and 100\u00a0mg\u00a0kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      BW) can dramatically promote learning and memory abilities. Mechanism studies demonstrate that KO reduces amyloid \u03b2 concentration by regulating the amyloidogenic pathway, inhibits neuro\u2010inflammation via regulating TLR4\u2010NLRP3 signaling pathway, and prevents neuron injure. KO supplementation also enhances gut barrier integrity, reduces serum lipopolysaccharide leakage, and alters the gut microbiota by reducing\n                      <jats:italic>Helicobacteraceae<\/jats:italic>\n                      ,\n                      <jats:italic>Lactobacillaceae<\/jats:italic>\n                      proportion, increasing\n                      <jats:italic>Dubosiella<\/jats:italic>\n                      and\n                      <jats:italic>Akkermansia<\/jats:italic>\n                      relative abundance. Particularly, a significant increase of isovaleric acid, propionic acid, and acetic acid levels is observed after KO supplementation. Correlation analysis shows that short\u2010chain fatty acids (SCFAs), gut microbiota, and cognitive function are strongly correlated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results reveal that KO relieves early mild cognitive impairment possibly for its role in mediating the gut microbiome\u2010SCFAs\u2010brain axis. Thus, KO may provide potential intervention strategies to prevent cognitive impairment in the early stages through the microbiota\u2010gut\u2010brain axis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mnfr.202200652","type":"journal-article","created":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T04:05:46Z","timestamp":1699416346000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Long\u2010Term Krill Oil Administration Alleviated Early Mild Cognitive Impairment in APP\/PS1 Mice"],"prefix":"10.1002","volume":"68","author":[{"given":"Yufeng","family":"Du","sequence":"first","affiliation":[{"name":"College of Marine Science and Biological Engineering Shandong Provincial Key Laboratory of Biochemical Engineering Qingdao University of Science and Technology  Qingdao Shandong 266042 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Song","sequence":"additional","affiliation":[{"name":"College of Marine Science and Biological Engineering Shandong Provincial Key Laboratory of Biochemical Engineering Qingdao University of Science and Technology  Qingdao Shandong 266042 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiufang","family":"Dong","sequence":"additional","affiliation":[{"name":"College of Marine Science and Biological Engineering Shandong Provincial Key Laboratory of Biochemical Engineering Qingdao University of Science and Technology  Qingdao Shandong 266042 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Li","sequence":"additional","affiliation":[{"name":"College of Marine Science and Biological Engineering Shandong Provincial Key Laboratory of Biochemical Engineering Qingdao University of Science and Technology  Qingdao Shandong 266042 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7010-1291","authenticated-orcid":false,"given":"Wancui","family":"Xie","sequence":"additional","affiliation":[{"name":"College of Marine Science and Biological Engineering Shandong Provincial Key Laboratory of Biochemical Engineering Qingdao University of Science and Technology  Qingdao Shandong 266042 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2310-1456","authenticated-orcid":false,"given":"Yuming","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Ocean University of China  Qingdao Shandong 266003 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9179-6830","authenticated-orcid":false,"given":"Hongxia","family":"Che","sequence":"additional","affiliation":[{"name":"College of Marine Science and Biological Engineering Shandong Provincial Key Laboratory of Biochemical Engineering Qingdao University of Science and Technology  Qingdao Shandong 266042 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,8]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11121925"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2021.12.004"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7FO01342F"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejlt.201800524"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8FO01822G"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2019.100997"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1750-3841.14044"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25173942"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.756822"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2018.07.006"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.17754"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1102999108"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.2c03142"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2018.09.002"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-020-0790-7"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.796288"},{"key":"e_1_2_9_17_1","first-page":"21","author":"Zhang T.","year":"2020","journal-title":"Int. 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