{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T14:35:15Z","timestamp":1782398115832,"version":"3.54.5"},"reference-count":49,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2023,7,23]],"date-time":"2023-07-23T00:00:00Z","timestamp":1690070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32002346"],"award-info":[{"award-number":["32002346"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Mycotoxins co\u2010contamination of agricultural products poses a serious threat to human and animal health, especially hepatic dysfunction. Zearalenone (ZEN), deoxynivalenol (DON), and aflatoxin B1 (AFB1) are three commonly co\u2010occurring mycotoxins. This study is to determine whether lycopene (LYC) can alleviate hepatic toxicity induced by the co\u2010occurrence of ZEN, DON, and AFB1 in mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Eighty 6\u2010week\u2010old male ICR mice are divided into four groups: CON group (solvent control), LYC group (10 mg\u00a0kg<jats:sup>\u22121<\/jats:sup> LYC), Co\u2010M group (10 mg\u00a0kg<jats:sup>\u22121<\/jats:sup> ZEN + 1 mg\u00a0kg<jats:sup>\u22121<\/jats:sup> DON + 0.5 mg\u00a0kg<jats:sup>\u22121<\/jats:sup> AFB1), and LYC+Co\u2010M group (10 mg\u00a0kg<jats:sup>\u22121<\/jats:sup> LYC + 10 mg\u00a0kg<jats:sup>\u22121<\/jats:sup> ZEN + 1 mg\u00a0kg<jats:sup>\u22121<\/jats:sup> DON + 0.5 mg\u00a0kg<jats:sup>\u22121<\/jats:sup> AFB1). The results show that LYC can suppress the co\u2010occurrence of mycotoxin\u2010induced mitochondrial swelling and vacuolization accompanied by dysregulation of indices of mitochondrial dynamics (<jats:italic>Mitofusin 1 (Mfn1)<\/jats:italic>, <jats:italic>Mfn2<\/jats:italic>, Optic atrophy 1 (<jats:italic>Opa1)<\/jats:italic>, Dynamin\u2010related protein 1 (<jats:italic>Drp1)<\/jats:italic>, Fission 1 (<jats:italic>Fis1)<\/jats:italic> at the mRNA level; DRP1 and FIS1 at the protein level). LYC effectively inhibits co\u2010occurrence of mycotoxin\u2010induced activation of Cytochrome P450 2E1, and early fibrosis, as determined by staining with Masson's trichrome and \u03b1\u2010SMA protein.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LYC successfully attenuates early hepatic fibrosis mainly through antioxidant activities and prevented mitochondrial injury.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202200671","type":"journal-article","created":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T00:15:10Z","timestamp":1690157710000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Co\u2010occurrence of Mycotoxin\u2010Induced Hepatotoxicity in Mice Inhibited by Lycopene: Mitochondrial Impairment and Early Hepatic Fibrosis"],"prefix":"10.1002","volume":"67","author":[{"given":"Jia","family":"Lin","sequence":"first","affiliation":[{"name":"Hubei Key Laboratory of Animal Nutrition and Feed Science, Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety Wuhan Polytechnic University  Wuhan 430023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianzeng","family":"Liang","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Animal Nutrition and Feed Science, Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety Wuhan Polytechnic University  Wuhan 430023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Huang","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Animal Nutrition and Feed Science, Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety Wuhan Polytechnic University  Wuhan 430023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuige","family":"Zuo","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Animal Nutrition and Feed Science, Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety Wuhan Polytechnic University  Wuhan 430023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Wang","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Animal Nutrition and Feed Science, Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety Wuhan Polytechnic University  Wuhan 430023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulan","family":"Liu","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Animal Nutrition and Feed Science, Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety Wuhan Polytechnic University  Wuhan 430023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,23]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.3769\/radioisotopes.36.11_563"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100930"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2010.04.011"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045151"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2014.10.020"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40104-019-0320-2"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins10030113"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins13070444"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10081313"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22010217"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10081268"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2021.503369"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13082539"},{"key":"e_1_2_9_14_1","first-page":"1","volume":"67","author":"Pall M. 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