{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:50:22Z","timestamp":1786978222195,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T00:00:00Z","timestamp":1684368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec>\n                    <jats:title>Scope<\/jats:title>\n                    <jats:p>Dityrosine (DT) is a protein oxidation marker present in many high\u2010protein foods, such as dairy and meat products. Chronic dietary intake of DT induces oxidative stress damage in the liver and impairs energy metabolism. This study aims to investigate the mechanisms underlying the effects of DT on disrupted hepatic energy metabolism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      The study investigates hepatic lipid accumulation, redox status imbalance, mitochondrial dysfunction, and energy metabolism disorders in 4\u2010week\u2010old C57BL\/6J mice after 35 days of DT (420 \u00b5g\u00a0kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      body weight) treatment. Transcriptome sequencing and quantitative real\u2010time PCR in HepG2 cells show that DT mainly acted via miR\u2010144\u20103p. miR\u2010144\u20103p targets immune responsive gene 1 (\n                      <jats:italic>IRG1<\/jats:italic>\n                      ) and decreases the fumaric acid level in the tricarboxylic acid (TCA) cycle, thereby decreasing nuclear factor erythroid 2\u2010related factor 2 (\n                      <jats:italic>Nrf2<\/jats:italic>\n                      ) expression and antioxidant activity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Administration of lycopene, a strong antioxidant, alleviates DT\u2010induced damage in mice, confirming the involvement of the\n                      <jats:italic>Nrf2<\/jats:italic>\n                      pathway in DT\u2010induced abnormal hepatic lipid metabolism and energy homeostasis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mnfr.202200674","type":"journal-article","created":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T05:44:53Z","timestamp":1680068693000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Dietary Dityrosine Induces Oxidative Stress and Mitochondrial\u2010Lipid Imbalance in Mouse Liver via MiR\u2010144\u20103p\u2010Mediated Downregulation of Nrf2"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3280-8392","authenticated-orcid":false,"given":"Xue","family":"Tang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Food Science and Technology Jiangnan University Wuxi Jiangsu 214122 China"},{"name":"School of Food Science and Technology Jiangnan University Wuxi Jiangsu 214122 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