{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T16:15:50Z","timestamp":1793722550812,"version":"4.6.1"},"reference-count":27,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2023,5,14]],"date-time":"2023-05-14T00:00:00Z","timestamp":1684022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Intestinal ischemia\u2010reperfusion (II\/R) injury is a common pathological process with high morbidity and mortality. Effective prevention and treatment therapies for II\/R are clinically necessary. 6\u2010Shogaol (6\u2010SG), the main active ingredient in dried ginger, behaviors multiple biological activities, including anti\u2010inflammation, antioxidation, and anti\u2010apoptosis. This study aims to elucidate the protective effects and mechanism of 6\u2010SG against II\/R\u2010induced injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Sprague\u2010Dawley rats are pre\u2010treated orally with 6\u2010SG and subjected to II\/R injury by clamping superior mesenteric artery for 1\u00a0h and reperfusion for 2\u00a0h. Caco\u20102 cells are challenged by hypoxia\/reoxygenation to mimic II\/R in vitro. 6\u2010SG pre\u2010treatment protects against II\/R injury by reducing intestinal morphological damage and intestinal barrier injury via inhibiting cell apoptosis. Network pharmacology and molecular docking analyses reveal\u00a0that 6\u2010SG has a high affinity with brain\u2010derived neurotrophic factor (BDNF) formed homodimer or heterodimer with NT4 instead of the monomer, and thus the dimer configuration is stabilized, activating BDNF\/TrkB\/PI3K\/AKT signaling pathway and inhibiting II\/R\u2010induced cell apoptosis. The outcome is further validated both in vivo and in vitro.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>6\u2010Shogaol protects against II\/R injury by inhibiting cell apoptosis through the BDNF\/TrkB\/PI3K\/AKT pathway. This study offers a new understanding of the protection mechanism of 6\u2010SG against II\/R\u2010induced injury.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202200773","type":"journal-article","created":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T06:25:28Z","timestamp":1682749528000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["6\u2010Shogaol from Dried Ginger Protects against Intestinal Ischemia\/Reperfusion by Inhibiting Cell Apoptosis via the BDNF\/TrkB\/PI3K\/AKT Pathway"],"prefix":"10.1002","volume":"67","author":[{"given":"Bin","family":"Li","sequence":"first","affiliation":[{"name":"College of Pharmacy Dalian Medical University  Dalian 116044 China"},{"name":"Dalian Anti\u2010Infective Traditional Chinese Medicine Development Engineering Technology Research Center  Dalian 116044 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunxiang","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Pharmacy Dalian Medical University  Dalian 116044 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Yuan","sequence":"additional","affiliation":[{"name":"College of Pharmacy Dalian Medical University  Dalian 116044 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanting","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Pharmacy Dalian Medical University  Dalian 116044 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunpeng","family":"Diao","sequence":"additional","affiliation":[{"name":"College of Pharmacy Dalian Medical University  Dalian 116044 China"},{"name":"Dalian Anti\u2010Infective Traditional Chinese Medicine Development Engineering Technology Research Center  Dalian 116044 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1468-7638","authenticated-orcid":false,"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Pharmacy Dalian Medical University  Dalian 116044 China"},{"name":"Dalian Anti\u2010Infective Traditional Chinese Medicine Development Engineering Technology Research Center  Dalian 116044 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,14]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-319770"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.17-137"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.08.067"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.854994"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.809621"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.844767"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15908"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00182.2019"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2021.07.038"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154034"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154147"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1970.01340280030009"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2022.134734"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2017.08.010"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/1028415X.2018.1520477"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201600274"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12358"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/1969482"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2012.07.001"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.882612"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12967"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.933641"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-017-0510-4"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201701096RR"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.92.317"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106099"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27165227"}],"container-title":["Molecular Nutrition &amp; 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