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The study attempts to explore association between magnesium status and single nucleotide polymorphisms (SNPs) of gene involved in magnesium absorption\u2010transient receptor potential membrane melastatin 6 (<jats:italic>TRPM6<\/jats:italic>) and gestational diabetes mellitus (GDM) risk<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>A nested case\u2013control study including 170 GDM cases and matched 340 controls is conducted based on Tongji Birth Cohort. Dietary, serum, and urine magnesium are evaluated before the diagnosis of GDM. Compared to the lowest tertile, women in the highest tertile of serum magnesium are at a lower risk of GDM (adjusted odds ratio [aOR] 0.42, 95% confidence intervals [CI] 0.21\u20130.84). Serum magnesium is inversely associated with insulin and homeostatic model assessment of insulin resistance (<jats:italic>\u03b2<\/jats:italic> = \u22120.05, <jats:italic>p<\/jats:italic> = 0.002; <jats:italic>\u03b2<\/jats:italic> = \u22120.04, <jats:italic>p<\/jats:italic> = 0.001, respectively). The aOR for GDM in carriers of the CT or CC genotypes of <jats:italic>TRPM6<\/jats:italic> rs2274924 compared with carriers of the TT genotype is 2.76 (95% CI 1.78\u20134.26). Dietary magnesium is positively associated with serum magnesium (<jats:italic>\u03b2<\/jats:italic> = 0.02, <jats:italic>p<\/jats:italic> = 0.004), but not with GDM risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum magnesium and the <jats:italic>TRPM6<\/jats:italic> rs2274924 polymorphism are associated with the risk of GDM.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202200835","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T04:36:20Z","timestamp":1695875780000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Magnesium Status, Genetic Variants of Magnesium\u2010Related Ion Channel Transient Receptor Potential Membrane Melastatin 6 (<i>TRPM6<\/i>) and the Risk of Gestational Diabetes Mellitus in Chinese Pregnant Women: A Nested Case\u2013Control Study"],"prefix":"10.1002","volume":"67","author":[{"given":"Shanshan","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, MOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College Huazhong University of Science and Technology  13 Hangkong Road Wuhan Hubei 430030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, MOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College Huazhong University of Science and Technology  13 Hangkong Road Wuhan Hubei 430030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, MOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College Huazhong University of Science and Technology  13 Hangkong Road Wuhan Hubei 430030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningning","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, MOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College Huazhong University of Science and Technology  13 Hangkong Road Wuhan Hubei 430030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, MOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College Huazhong University of Science and Technology  13 Hangkong Road Wuhan Hubei 430030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, MOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College Huazhong University of Science and Technology  13 Hangkong Road Wuhan Hubei 430030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, MOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College Huazhong University of Science and Technology  13 Hangkong Road Wuhan Hubei 430030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8844-0892","authenticated-orcid":false,"given":"Liping","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, MOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College Huazhong University of Science and Technology  13 Hangkong Road Wuhan Hubei 430030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Central Hospital of Wuhan Tongji Medical College Huazhong University of Science and Technology  26 Shengli Street Wuhan Hubei 430014 P. 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