{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T04:13:08Z","timestamp":1792383188066,"version":"4.4.0"},"reference-count":52,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T00:00:00Z","timestamp":1683244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Continuous ultraviolet (UV) exposure causes skin photoaging, wrinkle formation, and skin barrier damage. In this study, the protective effect of mixed probiotics (MP) against photoaging in UVB\u2010irradiated Hs68 fibroblasts and SKH\u20101 hairless mice is investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>The mice are irradiated with UVB for 8 weeks to induce photoaging, and MP (15 and 50\u00a0mg\u00a0day<jats:sup>\u22121<\/jats:sup>) is orally administered once a day. Skin parameters are measured in the dorsal skin and wrinkle formation factors are analyzed in skin replicas. To evaluate the mitogen\u2010activated protein kinase (MAPK) signaling pathway, western blotting and qRT\u2010PCR are performed. MP (50\u00a0mg\u00a0day<jats:sup>\u22121<\/jats:sup>) significantly improves skin moisture, transepidermal water loss, erythema, and skin thickness. MP also effectively suppresses wrinkle formation by regulating the transcriptional expression of matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs. MP also reduces inflammatory cytokine levels and phosphorylation of extracellular signaling regulatory kinase, Jun N\u2010terminal kinase, and p38 protein. Furthermore, the intestinal microbiome of the MP groups is significantly different compared with that of the UVB group, and the relative abundance of <jats:italic>Lactobacillus<\/jats:italic> and <jats:italic>Akkermansia<\/jats:italic> is significantly increased.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Collectively, these findings suggest that MP modulates the gut microbiome and ameliorates UVB\u2010induced photoaging by downregulating the MAPK pathway.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202200841","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T05:42:09Z","timestamp":1682055729000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Oral Administration of Mixed Probiotics Improves Photoaging by Modulating the Cecal Microbiome and MAPK Pathway in UVB\u2010Irradiated Hairless Mice"],"prefix":"10.1002","volume":"67","author":[{"given":"Eunsol","family":"Seo","sequence":"first","affiliation":[{"name":"WCU Biomodulation Major Department of Agricultural Biotechnology College of Agriculture and Life Sciences Seoul National University  Seoul 08826 South Korea"},{"name":"CH Labs Corp.  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Uiwang Gyeonggi\u2010do 14067 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung Joo","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Integrated Biomedical and Life Science Graduate School Korea University  Seoul 02841 South Korea"},{"name":"BK21FOUR R&amp;E Center for Learning Health Systems Korea University  Seoul 02841 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7016-9798","authenticated-orcid":false,"given":"Yejin","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Integrated Biomedical and Life Science Graduate School Korea University  Seoul 02841 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,5]]},"reference":[{"key":"e_1_2_9_1_1","first-page":"689","volume":"144","author":"Jensen J. M.","year":"2009","journal-title":"G. Ital. Dermatol. 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