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The previous study demonstrates that eicosapentaenoic acid\u2010enriched phospholipids (EPA\u2010PL) prevent body weight loss in a mouse model of CAC. However, the role of EPA\u2010PL on cancer\u2010induced skeletal muscle atrophy remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>In the present study, a Lewis lung carcinoma (LLC) mouse model is established, then the effect and underlying mechanism of EPA\u2010PL on skeletal muscle atrophy in LLC\u2010bearing mice are investigated. The results reveal that EPA\u2010PL treatment significantly attenuates skeletal muscle atrophy in LLC\u2010bearing mice, as evidenced by suppressing the reductions of skeletal muscle mass, myofiber cross\u2010sectional area, and grip strength. Besides, the study finds that EPA\u2010PL alleviated cancer\u2010induced skeletal muscle atrophy via balancing muscle protein degradation and synthesis, inhibiting type I oxidative muscle fibers atrophy, and promoting mitochondrial function. Furthermore, the results also indicate that EPA\u2010PL may counteract skeletal muscle atrophy in LLC mouse model via a sirtuin 1\u2010dependent mechanism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings provide evidence that EPA\u2010PL may be beneficial as a nutritional supplement for prevention and treatment of cancer\u2010induced skeletal muscle atrophy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202300033","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T07:15:54Z","timestamp":1683011754000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Eicosapentaenoic Acid\u2010Enriched Phospholipids Alleviate Skeletal Muscle Atrophy in Lewis Lung Carcinoma Mouse Model"],"prefix":"10.1002","volume":"67","author":[{"given":"Zi\u2010Jian","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Nutrition and Food Hygiene School of 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