{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:30:42Z","timestamp":1788233442632,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T00:00:00Z","timestamp":1693958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pericles.pericles-gcp.literatumonline.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Disruption of the one carbon metabolism during development, i.e., following a gestational vitamin B9 and B12 deficiencies, is involved in birth defects and brain development delay. Using a rat nutritional model, consisting of pups born to dams fed a vitamin B9 and B12 deficient diet (MDD), the study previously reports molecular and cellular alterations in the brain, in a sex dependent manner, with females being more affected than males. The study hypothesizes that epigenetic modifications could participate in the sex differences is observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>The study investigates lysine methylation of histones and expression of microRNAs in the cerebellum of MDD male and female pups. The study reports a differential regulation of H3K36Me2 and H4K20Me3 between males and females, in response to MDD. Moreover, distinct regulation of <jats:italic>Kmt5b<\/jats:italic> and <jats:italic>Kdm2a<\/jats:italic> expression by miR\u2010134\u20105p and miR\u2010369\u20105p from the <jats:italic>Dlk1\u2010Dio3<\/jats:italic> locus, contributes to the maintenance of expression of genes involved in synaptic plasticity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results could explain the neuroprotection to MDD that male pups display. The work will contribute to the understanding of the consequences of vitamin starvation on brain development, as well as how the epigenome is affected by one carbon metabolism disruption.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202300040","type":"journal-article","created":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T21:47:14Z","timestamp":1694036834000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cross\u2010Talk between miRNAs from the <i>Dlk1\u2010Dio3<\/i> Locus and Histone Methylation to Protect Male Cerebellum from Methyl Donor Deficiency"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8960-3710","authenticated-orcid":false,"given":"Jeremy","family":"Willekens","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Lorraine, Inserm NGERE  Nancy F\u201054000 France"},{"name":"CINJ Rutgers Cancer Institute of New Jersey  195 Little Albany St New Brunswick NJ 08901 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Mosca","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, Inserm NGERE  Nancy F\u201054000 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Burt\u2010Oberecken","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, Inserm NGERE  Nancy F\u201054000 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar","family":"Laugeais","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, Inserm NGERE  Nancy F\u201054000 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Kaoma","sequence":"additional","affiliation":[{"name":"Luxembourg Institute of Health Bioinformatics Platform, 1 A\u2010B  Luxembourg L\u20101445 Luxembourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6329-5542","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Bernardin","sequence":"additional","affiliation":[{"name":"Department of Cancer Research Luxembourg Institute of Health  Luxembourg L\u20101210 Luxembourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Vallar","sequence":"additional","affiliation":[{"name":"Luxembourg Institute of Health Bioinformatics Platform, 1 A\u2010B  Luxembourg L\u20101445 Luxembourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Dimofski","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, Inserm NGERE  Nancy F\u201054000 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Renaud","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, Inserm NGERE  Nancy F\u201054000 France"},{"name":"CHRU Nancy, H\u00f4pital d'enfants Service de G\u00e9n\u00e9tique Clinique  Nancy F\u201054000 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laetitia","family":"Lambert","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, Inserm NGERE  Nancy F\u201054000 France"},{"name":"CHRU Nancy, H\u00f4pital d'enfants Service de G\u00e9n\u00e9tique Clinique  Nancy F\u201054000 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Leheup","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, Inserm NGERE  Nancy F\u201054000 France"},{"name":"CHRU Nancy, H\u00f4pital d'enfants Service de G\u00e9n\u00e9tique Clinique  Nancy F\u201054000 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5067-042X","authenticated-orcid":false,"given":"Jean\u2010Louis","family":"Gu\u00e9ant","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, Inserm NGERE  Nancy F\u201054000 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Leininger\u2010Muller","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, Inserm NGERE  Nancy F\u201054000 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7108-5804","authenticated-orcid":false,"given":"Natacha","family":"Dreumont","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, Inserm NGERE  Nancy F\u201054000 France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,6]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01078-9"},{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a039099","volume":"14","author":"Gegenhuber B.","year":"2022","journal-title":"Cold Spring Harb. 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