{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:24:47Z","timestamp":1790742287722,"version":"4.1.0"},"reference-count":64,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T00:00:00Z","timestamp":1693785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["SD RGPIN\u20102018\u201004128"],"award-info":[{"award-number":["SD RGPIN\u20102018\u201004128"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pericles.pericles-gcp.literatumonline.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec>\n                    <jats:title>Scope<\/jats:title>\n                    <jats:p>Quinoa intake exerts hypoglycemic and hypolipidemic effects in animals and humans. Although peptides from quinoa inhibit key enzymes involved in glucose homeostasis in vitro, their in vivo antidiabetic properties have not been investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      This\u00a0study evaluated\u00a0the effect of oral administration of a quinoa protein hydrolysate (QH) produced through enzymatic hydrolysis and fractionation by electrodialysis with ultrafiltration membrane (EDUF) (FQH) on the metabolic and pregnancy outcomes of Lepdb\/+ pregnant mice, a preclinical model of gestational diabetes mellitus. The 4\u2010week pregestational consumption of 2.5\u00a0mg\u00a0mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      of QH in water prevented glucose intolerance and improves hepatic insulin signaling in dams, also reducing fetal weights. Sequencing and bioinformatic analyses of the defatted FQH (FQHD) identified 11 peptides 6\u201310 amino acids long that aligned with the quinoa proteome and exhibited putative anti\u2010dipeptidyl peptidase\u20104 (DPP\u2010IV) activity, confirmed in vitro in QH, FQH, and FDQH fractions. Peptides homologous to mouse and human proteins enriched for biological processes related to glucose metabolism are also identified.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Processing of quinoa protein may be used to develop a safe and effective nutritional intervention to control glucose intolerance during pregnancy. Further studies are required to confirm if this nutritional intervention is applicable to pregnant women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mnfr.202300047","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T00:40:45Z","timestamp":1693874445000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A Quinoa Protein Hydrolysate Fractionated by Electrodialysis with Ultrafiltration Membranes Improves Maternal and Fetal Outcomes in a Mouse Model of Gestational Diabetes Mellitus"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2113-1926","authenticated-orcid":false,"given":"Dolores","family":"Busso","sequence":"first","affiliation":[{"name":"Program of Reproductive Biology Research and Innovation Center School of Medicine Faculty of Medicine Universidad de los Andes  Santiago 7550000 Chile"},{"name":"Center of Interventional Medicine for Precision and Advanced Cellular Therapy (IMPACT) Universidad de los Andes  Santiago 7550000 Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adri\u00e1n","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Biopolymer Research and Engineering Lab (BiopREL) Research and Innovation Center School of Nutrition and Dietetics Faculty of Medicine Universidad de los Andes  Santiago 7550000 Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00e1s","family":"Santander","sequence":"additional","affiliation":[{"name":"Health Science Institute Universidad de O\u00b4Higgins  Rancagua 2841959 Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fujiko","family":"Saavedra","sequence":"additional","affiliation":[{"name":"Program of Reproductive Biology Research and Innovation Center School of Medicine Faculty of Medicine Universidad de los Andes  Santiago 7550000 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Pontificia Universidad Cat\u00f3lica de Chile  Santiago 8320000 Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Marette","sequence":"additional","affiliation":[{"name":"Institute of Nutrition and Functional Foods (INAF) Universit\u00e9 Laval  Qu\u00e9bec, Qu\u00e9bec G1V 0A6 Canada"},{"name":"Department of Anatomy and Physiology Faculty of Medicine Laval Hospital Research Center Universit\u00e9 Laval  Qu\u00e9bec, Qu\u00e9bec G1V 4G5 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Bazinet","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Physiology Faculty of Medicine Laval Hospital Research Center Universit\u00e9 Laval  Qu\u00e9bec, Qu\u00e9bec G1V 4G5 Canada"},{"name":"Department of Food Science and Nutrition Laboratoire de Transformation Alimentaire et Proc\u00e9d\u00e9s \u00c9lectroMembranaire (LTAPEM Laboratory of Food Processing and Electro\u2010Membrane Processes) 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