{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T09:13:48Z","timestamp":1778663628631,"version":"3.51.4"},"reference-count":48,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T00:00:00Z","timestamp":1690243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin City","doi-asserted-by":"publisher","award":["21JCQNJC01800"],"award-info":[{"award-number":["21JCQNJC01800"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin City","doi-asserted-by":"publisher","award":["20JCQNJC01860"],"award-info":[{"award-number":["20JCQNJC01860"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin City","doi-asserted-by":"publisher","award":["22JCZDJC00280"],"award-info":[{"award-number":["22JCZDJC00280"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Choroidal neovascularization (CNV) is age\u2010related macular degeneration's (AMD) main pathological change. High\u2010fat diet (HFD) is associated with a form of CNV; however, the specific mechanism is unclear. Mitochondrial dysfunction, characterized by abnormal acylcarnitine, occurs during metabolic screening of serum or other body tissues in AMD. This study investigates HFD's role in retinal and retinal pigment epithelium (RPE)\/choroidal acylcarnitine metabolism in CNV formation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Chow diet and HFD\u2010BN rats are laser\u2010treated to induce CNV. Acylcarnitine species are quantitatively characterized by ultrahigh\u2010performance liquid chromatography\u2010tandem mass spectrometry. Optical coherence tomography and fundus fluorescein angiography evaluate CNV severity. HFD promotes weight gain, dyslipidemia, and CNV formation. In CNV rats, few medium\u2010chain fatty acids (MCFAs) acylcarnitine in the RPE\/choroid are initially affected. When an HFD is administered to these, even MCFA acylcarnitine in the RPE\/choroid is found to decline. However, in the retina, odd acylcarnitines are increased, revealing \u201can opposite\u201d change within the RPE\/choroid, accompanied by influencing glycolytic key enzymes. The HFD+CNV group incorporated fewer long\u2010chain acylcarnitines, like C18:2, into the retina than controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HFD hastens choroidal neovascularization. The study comprehensively documented acylcarnitine profiles in a CNV rat model. Acylcarnitine's odd\u2010even and carbon\u2010chain length properties may guide\u00a0future therapeutics.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202300080","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T14:01:15Z","timestamp":1690293675000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["High\u2010Fat Diet Alters Acylcarnitine Metabolism of the Retina and Retinal Pigment Epithelium\/Choroidal Tissues in Laser\u2010Induced Choroidal Neovascularization Rat Models"],"prefix":"10.1002","volume":"67","author":[{"given":"Pinghui","family":"Wei","sequence":"first","affiliation":[{"name":"Clinical College of Ophthalmology Tianjin Medical University  Tianjin 300020 P. R. China"},{"name":"Tianjin Eye Hospital Tianjin Key Lab of Ophthalmology and Visual Science  Tianjin 300020 P. R. 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