{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T12:13:37Z","timestamp":1777032817392,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T00:00:00Z","timestamp":1707350400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Secretion of the gut hormones glucagon\u2010like peptide (GLP\u20101) and peptide YY (PYY) are induced by nutrients reaching the lower small intestine which regulate insulin and glucagon release, inhibit appetite, and may improve \u03b2\u2010cell regeneration. The aim is to test the effect of a slowly digested isomaltulose (ISO) compared to the rapidly digested saccharose (SAC) as a snack given 1\u00a0h before a standardized mixed meal test (MMT) on GLP\u20101, PYY, glucose\u2010dependent insulinotropic peptide (GIP), and metabolic responses in participants with or without type 2 diabetes (T2DM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Fifteen\u00a0healthy volunteers and 15 patients with T2DM consumed either 50\u00a0g ISO or SAC 1\u00a0h preload of MMT on nonconsecutive days. Clinical parameters and incretin hormones are measured throughout the whole course of MMT. Administration of 50\u00a0g ISO as compared to SAC induced a significant increase in GLP\u20101, GIP, and PYY responses over 2\u00a0h after intake of a typical lunch in healthy controls. Patients with T2DM showed reduced overall responses of GLP\u20101 and delayed insulin release compared to controls while ISO significantly enhanced the GIP and almost tripled the PYY response compared to SAC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A snack containing ISO markedly enhances the release of the metabolically advantageous gut hormones PYY and GLP\u20101 and enhances GIP release in response to a subsequent complex meal.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202300086","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T06:14:41Z","timestamp":1707459281000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Isomaltulose Enhances GLP\u20101 and PYY Secretion to a Mixed Meal in People With or Without Type 2 Diabetes as Compared to Saccharose"],"prefix":"10.1002","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8207-0149","authenticated-orcid":false,"given":"Jiudan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of Zhejiang Chinese Medical University  Youdian Road 54 Hangzhou 310000 China"},{"name":"Department of Endocrinology Diabetes and Nutrition Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominik","family":"Sonnenburg","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Diabetes and Nutrition Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"Department of Clinical Nutrition German Institute of Human Nutrition Potsdam\u2010Rehbr\u00fccke  Arthur\u2010Scheunert\u2010Allee 114\u2013116 14558 Nuthetal Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Tric\u00f2","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Pisa  Pisa 56126 Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1792-1757","authenticated-orcid":false,"given":"Stefan","family":"Kabisch","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Diabetes and Nutrition Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"Department of Clinical Nutrition German Institute of Human Nutrition Potsdam\u2010Rehbr\u00fccke  Arthur\u2010Scheunert\u2010Allee 114\u2013116 14558 Nuthetal Germany"},{"name":"German Center for Diabetes Research (Deutsches Zentrum F\u00fcr Diabetesforschung e.V.)  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