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Synbiotic as a novel alternative therapy for obesity have recently gained much attention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study innovatively research the anti\u2010obesity properties of a newly synbiotic composed of <jats:italic>Lactobacillus acidophilus, Bifidobacterium infantis<\/jats:italic> and konjac glucomannan oligosaccharides.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The synbiotic treatment can reduce body weight, fat mass, blood sugar, liver steatosis and adipose inflammation in obesity mice fed by high\u2010fat diet (HFD). Meanwhile, synbiotic treatment activated brown adipose tissue and improve energy, glucose and lipid metabolism. In addition, synbiotic treatment not solely enhanced the protection of intestinal barrier, but also ameliorated gut microbiota dysbiosis directly by enhancing beneficial microbes and reducing potentially harmful bacteria. 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