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However, the mechanisms by which increased dietary sugar affects RA etiology are not yet fully understood. The study uses a mouse model of collagen\u2010induced RA (CIA) to investigate the relationship between excessive sugar consumption and RA risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>RA\u2010associated pathological features are assessed in the nonimmunized (NI) control group, the CIA\u2010positive control group, and the CIA + high\u2010sucrose diet (CIA+HS, 63% calories from sucrose) group. Compared with the CIA group, the CIA+HS group shows a greater increase in paw thickness and clinical scores, as well as, a higher degree of pannus formation and inflammation in the knee, ankle, and sole tissues. Moreover, the infiltration of immune cells is increased in the CIA+HS group. Although the expression of hepatic lipogenic genes, is not altered, that of toll\u2010like receptor (TLR4) and IL\u20101\u03b2 is considerably elevated in the CIA+HS group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings suggest that excessive sucrose consumption causes hepatic fibrosis and inflammation, contributing to the pathophysiology of RA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202300244","type":"journal-article","created":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T05:45:57Z","timestamp":1694238357000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["High\u2010Sucrose Diet Accelerates Arthritis Progression in a Collagen\u2010Induced Rheumatoid Arthritis Model"],"prefix":"10.1002","volume":"67","author":[{"given":"Yunhui","family":"Min","sequence":"first","affiliation":[{"name":"Interdisciplinary Graduate Program in Advanced Convergence Technology and 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