{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:40:15Z","timestamp":1789584015592,"version":"build-2803163510"},"reference-count":67,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2023,12,24]],"date-time":"2023-12-24T00:00:00Z","timestamp":1703376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["BT\/PR32907\/MED\/122\/227\/2019"],"award-info":[{"award-number":["BT\/PR32907\/MED\/122\/227\/2019"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["BT\/PR38493\/TRM\/120\/465\/2020"],"award-info":[{"award-number":["BT\/PR38493\/TRM\/120\/465\/2020"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alzheimer's disease (AD) is the most prevalent dementia, affecting a large number of populations. Despite being under scrutiny for decades, an effective therapeutic option is still not available.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      This study explores the therapeutic role of a nootropic herb\n                      <jats:italic>Bacopa monnieri<\/jats:italic>\n                      (BM) in AD\u2010like pathological conditions produced by injecting preformed amyloid\u2010\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      (A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      ) fibril bilaterally into hippocampus of Wistar rats, and ethanolic extract of BM is orally administered for 4 weeks. Assessment of behavioral changes reveals that BM treatment ameliorates A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      \u2010induced cognitive impairment and compromised explorative behavior. Supplementation of BM also reduces oxidative stress biomarkers, proinflammatory cytokines, and cholinesterase activity in the AD rats. Additionally, BM treatment restores Bcl\u20102\u2010associated X protein (Bax)\/ B\u2010cell lymphoma 2 (Bcl\u20102) imbalance, increases neurotrophic factors expression, and prevents neurodegeneration validated by quantifying Nissl\u2010positive hippocampal neurons. Interestingly, BM administration eliminates amyloid plaques in the hippocampal region and normalizes the A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      \u2010induced increase in phospho\u2010tau and total tau expression. Mechanistic investigations reveal that BM interacts with glycogen synthase kinase (GSK\u20103\u03b2) and restores Wnt\/\u03b2\u2010catenin signaling.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>BM has been used in diet as a nootropic herb for several centuries. This study highlights the anti\u2010Alzheimer activity of BM from the behavioral to the molecular level by modulating mitochondrial dysfunction, and GSK\u20103\u03b2 mediates the Wnt\/\u03b2\u2010catenin signaling pathway.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mnfr.202300245","type":"journal-article","created":{"date-parts":[[2023,12,24]],"date-time":"2023-12-24T23:14:08Z","timestamp":1703459648000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Amelioration of Amyloid\u2010\u03b2 Induced Alzheimer's Disease by\n                    <i>Bacopa monnieri<\/i>\n                    through Modulation of Mitochondrial Dysfunction and GSK\u20103\u03b2\/Wnt\/\u03b2\u2010Catenin Signaling"],"prefix":"10.1002","volume":"68","author":[{"family":"Sushma","sequence":"first","affiliation":[{"name":"Laboratory of Cellular and Molecular Neurobiology School of Life Sciences Jawaharlal Nehru University  New Delhi 110067 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manas Ranjan","family":"Sahu","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular and Molecular Neurobiology School of Life Sciences Jawaharlal Nehru University  New Delhi 110067 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natarajan Arul","family":"Murugan","sequence":"additional","affiliation":[{"name":"Department of Computational Biology Indraprastha Institute of Information Technology  New Delhi 110067 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0491-7804","authenticated-orcid":false,"given":"Amal Chandra","family":"Mondal","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular and Molecular Neurobiology School of Life Sciences Jawaharlal Nehru University  New Delhi 110067 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,24]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00014176"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12638"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-6606-4-1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.07.327"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.617588"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.409250"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014382"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001208"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-385975-4.00008-5"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.06566.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1381-04.2004"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/301575"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2004.02.028"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-020-02116-9"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-021-06236-w"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.6b00438"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2008.07.039"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2006-9303"},{"key":"e_1_2_9_19_1","first-page":"285","volume":"3","author":"Goswami S.","year":"2011","journal-title":"Int. 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