{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T01:16:14Z","timestamp":1792977374635,"version":"4.5.0"},"reference-count":56,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec>\n                    <jats:title>Scope<\/jats:title>\n                    <jats:p>Depression is a severe mental condition, common among menopausal women. \u03b3\u2010Oryzanol (ORY) has various biological properties; however, the effect of ORY on menopausal depression and its underlying mechanisms have not been investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>ORY is orally administered to ovariectomized (OVX) mice for 20 weeks. ORY administration results in lower immobility time in the tail suspension and forced swim test and increases locomotor activity in the open field test. In the primary hippocampal neurons and hippocampi of OVX mice, ORY treatment increases nitric oxide (NO) production and neuronal NO synthase (nNOS) expression. Further, the phosphorylation of extracellular signal\u2010regulated kinase (ERK), cAMP response element\u2010binding protein (CREB), and tropomyosin receptor kinase B, along with the expression of brain\u2010derived neurotrophic factior (BDNF), is upregulated. These stimulatory effects of ORY are diminished by treatment with estrogen receptor \u03b2 (ER\u03b2) antagonist. ORY similarly interacts with ER\u03b2 in the molecular docking analysis. Moreover,\u00a0intracerebroventricular injection of 7\u2010nitroindazole, a nNOS inhibitor, abolishes the antidepressant effects of ORY.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results indicate that ORY attenuates depressive behavior in OVX mice by upregulating ER\u03b2\u2010mediated hippocampal nNOS expression and activating the ERK\u2010CREB\u2010BDNF signaling networks. The findings suggest that ORY is a potential therapeutic agent for attenuating menopausal depression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mnfr.202300253","type":"journal-article","created":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T13:21:08Z","timestamp":1701868868000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["\u03b3\u2010Oryzanol Ameliorates Depressive Behavior in Ovariectomized Mice by Regulating Hippocampal Nitric Oxide Synthase: A Potential Therapy for Menopausal Depression"],"prefix":"10.1002","volume":"68","author":[{"given":"Minji","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Functional Food Research Korea Food Research Institute Wanju 55365 Republic of Korea"},{"name":"Department of Food Biotechnology University of Science &amp; Technology Daejeon 34113 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minseok","family":"Yoon","sequence":"additional","affiliation":[{"name":"Division of Functional Food Research Korea Food Research Institute Wanju 55365 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suengmok","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology\/Institute of Food Science Pukyong National University Busan 48513 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changho","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Functional Food Research Korea Food Research Institute Wanju 55365 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8448-8837","authenticated-orcid":false,"given":"Min Young","family":"Um","sequence":"additional","affiliation":[{"name":"Division of Functional Food Research Korea Food Research Institute Wanju 55365 Republic of Korea"},{"name":"Department of Food Biotechnology University of Science &amp; Technology Daejeon 34113 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,6]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32279-7"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.150205"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(02)00432-9"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.58.6.529"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-011-1848-9"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.04.028"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2003.08.010"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2004.02792.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70209-7"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-1375"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1207461109"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11040728"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11040753"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphs.2018.06.003"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00330"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-006-0326-2"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2019.04.013"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0004-11.2011"},{"key":"e_1_2_9_19_1","volume":"135","author":"Xavier A. 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