{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T10:10:45Z","timestamp":1775124645571,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004431","name":"Fondation de France","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004431","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022077","name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022077","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007586","name":"Aix-Marseille Universit\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Vitamin D deficiency (VDD) is becoming a global issue and low 25\u2010hydroxyvitamin D (25(OH)D) plasma levels have been linked to hepatic steatosis in adulthood. Nevertheless, the impact of maternal VDD on lipid metabolism and hepatic steatosis remains poorly documented, especially under obesogenic condition. The goal of this study is to assess the effects of maternal VDD on hepatic lipid accumulation in adult offspring fed a normal or obesogenic diet.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Several approaches are implemented including histology and lipidomics on the liver in both males and females. No major impact of high\u2010fat (HF) or VDD is observed at histological level in both males and females. Nevertheless, in males born from VDD mice and fed an HF diet, an increase of total lipids and modulation of the relative lipid species distribution characterized by a decrease of triglycerides and increase of phospholipids is observed. In female no major lipid profile is noticed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Maternal VDD combined with a HF diet in male may predispose to hepatic hypertrophia, with a specific lipid profile. Such observations reinforce our knowledge of the impact of maternal VDD on hepatic programming in the offspring.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202300290","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T01:04:19Z","timestamp":1701133459000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Maternal Vitamin D Deficiency in Mice Sex\u2010Dependently Affects Hepatic Lipid Accumulation in Offspring"],"prefix":"10.1002","volume":"68","author":[{"given":"Nicole","family":"Haroun","sequence":"first","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9 C2VN INRAE INSERM  Marseille 13000 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imene","family":"Bennour","sequence":"additional","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9 C2VN INRAE INSERM  Marseille 13000 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Seipelt","sequence":"additional","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9 C2VN INRAE INSERM  Marseille 13000 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Astier","sequence":"additional","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9 C2VN INRAE INSERM  Marseille 13000 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e9a","family":"Sani","sequence":"additional","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9 C2VN INRAE INSERM  Marseille 13000 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Tardivel","sequence":"additional","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9 C2VN INRAE INSERM  Marseille 13000 France"},{"name":"Biomet C2VN CriBiom  Marseille 13000 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ljubica","family":"Svilar","sequence":"additional","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9 C2VN INRAE INSERM  Marseille 13000 France"},{"name":"Biomet C2VN CriBiom  Marseille 13000 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Charles","family":"Martin","sequence":"additional","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9 C2VN INRAE INSERM  Marseille 13000 France"},{"name":"Biomet C2VN CriBiom  Marseille 13000 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9221-5783","authenticated-orcid":false,"given":"Lourdes","family":"Mounien","sequence":"additional","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9 C2VN INRAE INSERM  Marseille 13000 France"},{"name":"PhenoMARS C2VN CriBiom  Marseille 13000 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8690-8014","authenticated-orcid":false,"given":"Jean","family":"Fran\u00e7ois Landrier","sequence":"additional","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9 C2VN INRAE INSERM  Marseille 13000 France"},{"name":"PhenoMARS C2VN CriBiom  Marseille 13000 France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,27]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2013.11.003"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.115.120873"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuy034"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.13453"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14102049"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665115004164"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu4111622"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.12.054"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41430-018-0323-7"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.13981"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12113302"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i6.1718"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2019.105399"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11010077"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12020342"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000002664"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2017.01.008"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ando.2021.11.010"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201902924RR"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11132024"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201601083"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2017.01.004"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.D700041-JLR200"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.120.313955"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp356"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20701"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v12.i8.436"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2017.50"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.149.6.1215"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2014.05.002"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2023.115621"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2017.04.006"}],"container-title":["Molecular Nutrition &amp; Food Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.202300290","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T04:50:07Z","timestamp":1705726207000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mnfr.202300290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,27]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1002\/mnfr.202300290"],"URL":"https:\/\/doi.org\/10.1002\/mnfr.202300290","archive":["Portico"],"relation":{},"ISSN":["1613-4125","1613-4133"],"issn-type":[{"value":"1613-4125","type":"print"},{"value":"1613-4133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,27]]},"assertion":[{"value":"2023-05-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2300290"}}