{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T04:22:08Z","timestamp":1778300528858,"version":"3.51.4"},"reference-count":53,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:00:00Z","timestamp":1696464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81904240"],"award-info":[{"award-number":["81904240"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Endometrial receptivity plays a vital role in embryonic implantation.<jats:italic>Yueliang Yin<\/jats:italic>is a marketed solid drink in China, also known as<jats:italic>Bushen Cuyun<\/jats:italic>Recipe (BCR), that is, assumed to have a therapeutic effect on infertility by improving endometrial receptivity. This study investigates the effects and mechanisms of BCR in protecting the endometrium.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Mice with mifepristone\u2010induced embryo implantation failure that exhibited a decreased implantation sites number, thinner endometrium, reduced endometrial glands number, and poor pinopode expression levels are treated with BCR, and these mentioned conditions significantly improves afterward. Molecular docking shows that the main active components kaempferol, quercetin, and hesperetin of BCR stably bound to gasdermin D (GSDMD). Experimental results demonstrate that levels of GSDMD, cleaved caspase\u20101 and leucine\u2010rich repeat, and pyrin domain\u2010containing 3 and IL\u20101\u03b2 levels in model mice are significantly decreased and expressions of brain\u2010derived neurotrophic factor (BDNF) and tyrosine protein kinase B (TrkB) expression levels are significantly elevated after BCR treatments, and that the DNA damage is significantly reversed in BCR\u2010treated mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>BCR is potent and effective in ameliorating endometrial receptivity. The potential mechanisms of BCR on endometrial receptivity may mediate by activating BDNF\/TrkB pathway activation and protecting endometrial cells' protection against pyroptosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202300339","type":"journal-article","created":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T17:26:54Z","timestamp":1696613214000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Yueliang Yin Ameliorates Endometrial Receptivity in Mice with Embryo Implantation Failure by Reducing Pyroptosis and Activating BDNF\/TrkB Pathway"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6728-9406","authenticated-orcid":false,"given":"Mei","family":"Jiang","sequence":"first","affiliation":[{"name":"Beijing Research Institute of Chinese Medicine Beijing University of Chinese Medicine Beijing 100029 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine Beijing University of Chinese Medicine Beijing 100029 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxi","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Life Sciences Beijing University of Chinese Medicine Beijing 100029 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Life Sciences Beijing University of Chinese Medicine Beijing 100029 China"},{"name":"National Key Laboratory of Efficacy and Mechanism on Chinese Medicine for Metabolic Diseases Beijing University of Chinese Medicine Beijing 100029 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianjun","family":"Kang","sequence":"additional","affiliation":[{"name":"Beijing Research Institute of Chinese Medicine Beijing University of Chinese Medicine Beijing 100029 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cong","family":"Chen","sequence":"additional","affiliation":[{"name":"Beijing Research Institute of Chinese Medicine Beijing University of Chinese Medicine Beijing 100029 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujie","family":"Hu","sequence":"additional","affiliation":[{"name":"Ziqiang Vocational School of Shaanxi Province Shaanxi Province 721000 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jialin","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Research Institute of Chinese Medicine Beijing University of Chinese Medicine Beijing 100029 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Research Institute of Chinese Medicine Beijing University of Chinese Medicine Beijing 100029 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,5]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew082"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2014.10.002"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmaa040"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmm011"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)44469-9"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0083-6729(08)60999-1"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2018.12.027"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.11.565"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-017-0922-6"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.03.091"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2013.02.007"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12493"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12559"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2014.906571"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.541537"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-019-2472-1"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/micc.12581"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2011.05.037"},{"key":"e_1_2_9_19_1","first-page":"1998","volume":"33","author":"Li J.","year":"2018","journal-title":"Acta Chin. 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