{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:26:17Z","timestamp":1789655177258,"version":"4.0.1"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T00:00:00Z","timestamp":1707350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Edible insects contain allergens with potential cross\u2010reactivity to other invertebrates. Here, this study examines IgE\u2010reactive proteins in a house cricket snack (<jats:italic>Acheta domesticus<\/jats:italic>) leading to an allergic reaction in a 27\u2010year old man followed by a similar reaction days later after eating shrimps.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Prick to prick tests verify the IgE\u2010mediated allergy to crickets and skin prick testing confirms a type I sensitization to house dust mite without any clinical relevance for the patient, and to shrimp extracts, but is negative for several other foods. Serological testing reveals a sensitization to shrimps, shrimp tropomyosin, and house dust mite tropomyosin. IgE\u2010immunodetection shows that the cricket allergic patient is sensitized to two proteins of 45 and &gt;97\u00a0kDa using aqueous control cricket extract, but to only one protein at around 45\u00a0kDa when using the causative, seasoned insect snack extract. Mass spectrometry data and IgE\u2010inhibition experiments clearly identify this protein belonging to the tropomyosin allergen family.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This case report suggests that cricket tropomyosin may be an elicitor of allergic reactions even in previously not allergic patients, although it cannot be excluded the patient reacted additionally to other ingredients of the snack.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202300420","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T06:14:44Z","timestamp":1707459284000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Allergic Reaction to a Commercially Available Insect Snack Caused by House Cricket (<i>Acheta domesticus<\/i>) Tropomyosin"],"prefix":"10.1002","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5184-5455","authenticated-orcid":false,"given":"Andrea","family":"Wangorsch","sequence":"first","affiliation":[{"name":"Molecular Allergology Paul\u2010Ehrlich\u2010Institut  63225 Langen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Jamin","sequence":"additional","affiliation":[{"name":"Molecular Allergology Paul\u2010Ehrlich\u2010Institut  63225 Langen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Spiric","sequence":"additional","affiliation":[{"name":"Division of Allergology Paul\u2010Ehrlich\u2010Institut  63225 Langen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Vieths","sequence":"additional","affiliation":[{"name":"Molecular Allergology Paul\u2010Ehrlich\u2010Institut  63225 Langen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Scheurer","sequence":"additional","affiliation":[{"name":"Molecular Allergology Paul\u2010Ehrlich\u2010Institut  63225 Langen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Mahler","sequence":"additional","affiliation":[{"name":"Division of Allergology Paul\u2010Ehrlich\u2010Institut  63225 Langen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke C.","family":"Hofmann","sequence":"additional","affiliation":[{"name":"Center for Dermatology, Allergology and Dermatosurgery HELIOS University Hospital Wuppertal, University of Witten\/Herdecke  42283 Wuppertal Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,8]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-021-01012-z"},{"key":"e_1_2_9_2_1","volume":"19","author":"Ros\u2010Bar\u00f3 M.","year":"2022","journal-title":"Int. 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