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The human body experiences rapid cell division and metabolism until approximately 25 years of age, after which the accumulation of metabolic by\u2010products and cellular damage leads to age\u2010related diseases. Neurodegenerative diseases are of concern due to their irreversible nature, lack of effective treatment, and impact on society and the economy. Researchers are interested in finding drugs that can effectively alleviate ageing and age\u2010related diseases without side\u2010effects. Psychobiotics are a novel class of probiotic organisms and prebiotic interventions that confer mental health benefits to the host when taken appropriately. Psychobiotic strains affect functions related to the central nervous system (CNS) and behaviors mediated by the Gut\u2010Brain\u2010Axis (GBA) through various pathways. There is an increasing interest in researchers of these microbial\u2010based psychopharmaceuticals. Psychobiotics have been reported to reduce neuronal ageing, inflammation, oxidative stress, and cortisol levels; increase synaptic plasticity and levels of neurotransmitters and antioxidants. The present review focuses on the manifestation of elderly neurodegenerative and mental disorders, particularly Alzheimer's disease (AD), Parkinson's disease (PD), and depression, and the current status of their potential alleviation through psychobiotic interventions, highlighting their possible mechanisms of action.<\/jats:p>","DOI":"10.1002\/mnfr.202300461","type":"journal-article","created":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T03:13:24Z","timestamp":1694834004000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Psychobiotics for Mitigation of Neuro\u2010Degenerative Diseases: Recent Advancements"],"prefix":"10.1002","volume":"68","author":[{"given":"Priya","family":"Dhyani","sequence":"first","affiliation":[{"name":"Department of Dairy Science &amp; Food Technology Institute of Agricultural Sciences BHU  Varansi 121005 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chhaya","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Dairy Science &amp; Food Technology Institute of Agricultural Sciences BHU  Varansi 121005 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5749-6241","authenticated-orcid":false,"given":"Sanju Bala","family":"Dhull","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology Chaudhary Devi Lal University  Sirsa 125055 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil Kumar","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Department of Dairy Science &amp; Food Technology Institute of Agricultural Sciences BHU  Varansi 121005 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baljeet","family":"Singh Saharan","sequence":"additional","affiliation":[{"name":"Department of Microbiology CCS Haryana Agricultural University  Hisar 125 004 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Harshita","sequence":"additional","affiliation":[{"name":"West China School of Medicine Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joginder Singh","family":"Duhan","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Chaudhary Devi Lal University  Sirsa 125055 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5432-7936","authenticated-orcid":false,"given":"Gulden","family":"Goksen","sequence":"additional","affiliation":[{"name":"Department of Food Technology Vocational School of Technical Sciences at Mersin Tarsus Organized Industrial Zone Tarsus University  Mersin 33100 T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,15]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms7010014"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-021-00043-5"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190062"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.634069"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-017-0600-5"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/6626513"},{"key":"e_1_2_9_7_1","first-page":"324","volume":"70","author":"Singh A.","year":"2017","journal-title":"Ind. 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