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Blood pressure (BP) is monitored using implantable telemetry technology. Over 18\u2010day oral administration of 15\u00a0mg\u00a0kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      body weight (BW) per day, only peptide V\u2010F significantly (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05) reduces BP, decreases circulating Ang II, and increases ACE2 and Ang (1\u20107) levels, and enhances aortic expressions of ACE2 and Mas receptor (MasR). Peptide V\u2010F also attenuates vascular inflammation (TNF\u03b1, MCP\u20101, IL\u20101\u03b1, IL\u201015, and cyclooxygenase 2 [COX2]) and vascular oxidative stress (nitrotyrosine). The gastrointestinal (GI)\u2010degraded fragment of peptide V\u2010F, Val\u2010Val\u2010His\u2010Pro\u2010Lys (VVHPK), is also an ACE2\u2010upregulating peptide. Peptides VRP, LKY, and VRY do not reduce BP, possibly due to low bioavailability or other unknown reasons.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Peptide V\u2010F is the first ACE2\u2010upregulating peptide, purified and fractionated from food proteins based on in vitro ACE2 upregulation, that reduces BP associated with the activation of ACE2\/Ang (1\u20107)\/MasR axis; the N\u2010terminal moiety VVHPK may be responsible for the antihypertensive effect of V\u2010F.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mnfr.202300524","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T21:23:37Z","timestamp":1707945817000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Chicken Muscle\u2010Derived ACE2\u2010Upregulating Peptide VVHPKESF Reduces Blood Pressure Associated with the ACE2\/Ang (1\u20107)\/MasR Axis in Spontaneously Hypertensive Rats"],"prefix":"10.1002","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1049-6815","authenticated-orcid":false,"given":"Hongbing","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Agricultural Food and Nutritional Science University of Alberta  4\u201010 Ag\/For Building Edmonton Alberta T6G 2P5 Canada"},{"name":"Cardiovascular Research Centre University of Alberta  Edmonton Alberta T6G 2R7 Canada"},{"name":"Department of Animal and Food Sciences University of Kentucky  Lexington KY 40546 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8620-4631","authenticated-orcid":false,"given":"Nan","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Agricultural Food and Nutritional Science University of Alberta  4\u201010 Ag\/For Building Edmonton Alberta T6G 2P5 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra T.","family":"Davidge","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Centre University of Alberta  Edmonton Alberta T6G 2R7 Canada"},{"name":"Department of Obstetrics and Gynecology University of Alberta  Edmonton Alberta T6G 2R7 Canada"},{"name":"Department of Physiology University of Alberta  Edmonton Alberta T6G 2R7 Canada"},{"name":"Women and Children's Health Research Institute University of Alberta  Edmonton Alberta T6G 2R7 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Agricultural Food and Nutritional Science University of Alberta  4\u201010 Ag\/For Building Edmonton Alberta T6G 2P5 Canada"},{"name":"Cardiovascular Research Centre University of Alberta  Edmonton Alberta T6G 2R7 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,14]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.11.005"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31919-5"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(01)02321-9"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms16010256"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60242-6"},{"key":"e_1_2_9_6_1","first-page":"639","volume":"52","author":"Touyz R. 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