{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T23:15:11Z","timestamp":1776467711032,"version":"3.51.2"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T00:00:00Z","timestamp":1702339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["10.55776\/KLI784"],"award-info":[{"award-number":["10.55776\/KLI784"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Human milk oligosaccharides (HMOs) are bioactive glycans first detected in human milk. Their presence in maternal blood during pregnancy suggests systemic functions. Dynamics and associations of the most abundant prenatal HMOs in relation to maternal BMI and serum lipids in a cohort of 87 pregnant women with either overweight or obesity are studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum HMOs (2\u2019FL, 3\u2019SL, 3\u2019SLN, LDFT), serum lipids (total cholesterol, HDL, LDL, triglycerides), and BMI are measured at 15, 24, and 32 weeks of gestation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>2\u2019FL and LDFT are negatively correlated to pre\u2010pregnancy BMI and increase significantly slower between 15 and 24 weeks in highly obese women. Women without detectable increase of serum 2\u2019FL (non\u2010secretors) show a less pronounced gestational weight gain and lower BMI in the third trimester as compared to women phenotype as secretors. Higher early\u2010pregnancy 2\u2019FL is associated with high HDL and low triglycerides in pregnancy. On the other hand, higher 3\u2019SL at 15 weeks is associated with higher triglycerides, LDL, and total cholesterol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Higher early\u2010pregnancy 2\u2019FL is associated with a cardioprotective lipid profile, whereas higher 3\u2019SL is associated with an atherogenic lipid profile. Serum trajectories of 2\u2019FL and LDFT in obese women suggest an obesity mediated delay of \u03b1\u20101,2\u2010fucosylation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202300533","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:31:50Z","timestamp":1702427510000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prenatal Human Milk Oligosaccharides (HMOs) in the Context of BMI, Gestational Weight Gain, and Lipid Profile\u2014An Association Study in Pregnant Women with Overweight or Obesity"],"prefix":"10.1002","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3066-9683","authenticated-orcid":false,"given":"Lukas","family":"Sch\u00f6nbacher","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Medical University of Graz  Auenbruggerplatz 14 Graz 8036 Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Treichler","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Medical University of Graz  Auenbruggerplatz 14 Graz 8036 Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waltraud","family":"Brandl","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Medical University of Graz  Auenbruggerplatz 14 Graz 8036 Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald C.","family":"K\u00f6feler","sequence":"additional","affiliation":[{"name":"BioTechMed\u2010Graz  Mozartgasse 12\/II Graz 8010 Austria"},{"name":"Center for Medical Research Medical University of Graz  Stiftingtalstra\u00dfe 24 Graz 8010 Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herbert","family":"Fluhr","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Medical University of Graz  Auenbruggerplatz 14 Graz 8036 Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3568-891X","authenticated-orcid":false,"given":"Evelyn","family":"Jantscher\u2010Krenn","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Medical University of Graz  Auenbruggerplatz 14 Graz 8036 Austria"},{"name":"BioTechMed\u2010Graz  Mozartgasse 12\/II Graz 8010 Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mireille N. 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