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S\n                      <jats:sub>LBL<\/jats:sub>\n                      and its physical mixture (M\n                      <jats:sub>LBL<\/jats:sub>\n                      ) do not significantly inhibit obesity in mice. However, S\n                      <jats:sub>LBL<\/jats:sub>\n                      treatment increases the ratio of n3\/n6 fatty acids in the liver and improves obesity\u2010induced hepatic lipid metabolism disorders. Furthermore, the expression of liver pro\u2010inflammatory cytokines (interleukin [IL]\u20106, IL\u20101\u03b2, TNF\u2010\u03b1) are significantly suppressed by S\n                      <jats:sub>LBL<\/jats:sub>\n                      , while the expression of anti\u2010inflammatory cytokine (IL\u201010) is increased. Moreover, S\n                      <jats:sub>LBL<\/jats:sub>\n                      ameliorates the dysbiosis of small intestinal microbes induced by high\u2010fat diet and regulates microbial community structure to be close to the control group. Especially, S\n                      <jats:sub>LBL<\/jats:sub>\n                      significantly alleviates the high\u2010fat diet\u2010induced decrease in\n                      <jats:italic>Dubosiella<\/jats:italic>\n                      and\n                      <jats:italic>Bifidobacterium<\/jats:italic>\n                      abundance. Correlation analysis reveals that S\n                      <jats:sub>LBL<\/jats:sub>\n                      treatment increases the abundance of microorganisms with potential anti\u2010inflammatory function and decreases the abundance of potentially pathogenic bacteria.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      In all, small intestinal microbes may be a significant bridge for the positive anti\u2010inflammatory effects of S\n                      <jats:sub>LBL<\/jats:sub>\n                      , while the exact mechanism remains to be clarified.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mnfr.202300535","type":"journal-article","created":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T19:02:29Z","timestamp":1701457349000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Novel Lauric Acid\u2010Butyric Structural Lipid Inhibits Inflammation: Small Intestinal Microbes May Be Important Mediators"],"prefix":"10.1002","volume":"68","author":[{"given":"Wangxin","family":"Liu","sequence":"first","affiliation":[{"name":"College of Biosystems Engineering and Food Science Zhejiang University  Hangzhou 310058 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjie","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Biosystems Engineering and Food Science Zhejiang University  Hangzhou 310058 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Biosystems Engineering and Food Science Zhejiang University  Hangzhou 310058 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengqin","family":"Feng","sequence":"additional","affiliation":[{"name":"College of Biosystems Engineering and Food Science Zhejiang University  Hangzhou 310058 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4162-1316","authenticated-orcid":false,"given":"Xianliang","family":"Luo","sequence":"additional","affiliation":[{"name":"College of Biosystems Engineering and Food Science Zhejiang University  Hangzhou 310058 China"},{"name":"College of Food Science Fujian Agriculture and Forestry University  Fuzhou 350002 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Ningbo Innovation Center Zhejiang University  Ningbo 315100 China"},{"name":"College of Biosystems Engineering and Food Science Zhejiang University  Hangzhou 310058 China"},{"name":"Guangdong Qingyunshan Pharmaceutical Co., Ltd.  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