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Hypothyroidism\u2010associated ophthalmopathy (HAO), often known as dry eyes, swelling around the eyes, blurred vision, glaucoma, and cataracts, are some eye\u2010related issues caused by hypothyroidism. Yet there is no permanent cure for hypothyroidism; taking medicine throughout life is the only solution to keep its harmful effects under control. This study used intermittent fasting (IF) and vitamin E (Vit.E)\u00a0supplementation to prevent hypothyroidism\u2010associated ophthalmopathy. This study hypothesized that intermittent fasting\u2010like diet regimens and vitamin supplementation should reduce the propagation of HAO by its antioxidant potential. In the present study, experimental animals are divided into five groups: normal, hypothyroidism control, dual, Vit. E, and IF. Hypothyroidism is generated in the experimental groups by taking propylthiouracil (PTU) for 24 days while also taking IF and Vit.\u00a0E\u00a0supplements. The hypothyroid\u2010induced experimental animals demonstrated an increase in IOP and lipid peroxidation while thyroid hormone levels depicted a massive decline which is a clear denotation of the effects of the thyroid on eyes and lifestyle. Ancient Ayurveda inspires these proposed therapies and has successfully reduced all the damage to the thyroid gland and the eye.<\/jats:p>","DOI":"10.1002\/mnfr.202300589","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T02:19:09Z","timestamp":1707704349000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Intermittent Fasting and Vitamin E Supplementation Attenuates Hypothyroidism\u2010Associated Ophthalmopathy"],"prefix":"10.1002","volume":"68","author":[{"given":"Nirdesh","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Pharmacy Guru Ghasidas Vishwavidyalaya (A Central University)  Koni Bilaspur Chhattisgarh 495009 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashmita","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Guru Ghasidas Vishwavidyalaya (A Central University)  Koni Bilaspur Chhattisgarh 495009 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nidhi","family":"Kumari","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Guru Ghasidas Vishwavidyalaya (A Central University)  Koni Bilaspur Chhattisgarh 495009 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geeta","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Guru Ghasidas Vishwavidyalaya (A Central University)  Koni Bilaspur Chhattisgarh 495009 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urvashi","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Guru Ghasidas Vishwavidyalaya (A Central University)  Koni Bilaspur Chhattisgarh 495009 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amrita","family":"Singh","sequence":"additional","affiliation":[{"name":"National Institute of pharmaceutical education and research (NIPER) Ahmedabad  Gandhinagar Gujarat 382355 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9399-8337","authenticated-orcid":false,"given":"Surendra H.","family":"Bodakhe","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Guru Ghasidas Vishwavidyalaya (A Central University)  Koni Bilaspur Chhattisgarh 495009 India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,11]]},"reference":[{"key":"e_1_2_9_1_1","first-page":"82","volume":"14","author":"Athanassiou I. 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