{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:43:39Z","timestamp":1790660619750,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T00:00:00Z","timestamp":1708560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"publisher","award":["2018JM7081"],"award-info":[{"award-number":["2018JM7081"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Comprehensive assessment of <jats:sc>l<\/jats:sc>\u2010carnitine's safety and effectiveness in reducing inflammatory markers in osteoarthritis (OA) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Journal articles on <jats:sc>l<\/jats:sc>\u2010carnitine for OA are gathered using computer searches of PubMed, Embase, the Cochrane Library, and Web of Science. The kind of literature that is found is restricted to clinical randomized controlled trials (RCTs). The Cochrane Handbook risk of bias assessment tool RevMan 5.4 software is used to conduct a meta\u2010analysis. The systematic assessment comprises eight trials totaling 619 patients; the included studies\u2019 quality is mediocre. The study's findings demonstrate that OA patients\u2019 Western Ontario and McMaster University (WOMAC) function improves and that treatment efficacy outperforms that of the control group (mean difference [MD] = \u22127.75, 95% CI [\u221214.63, \u22120.86]; <jats:italic>Z<\/jats:italic> = 2.21; <jats:italic>p<\/jats:italic> = 0.03), WOMAC total (MD = \u221210.24, 95% CI [\u221218.97, \u22121.51]; <jats:italic>Z<\/jats:italic> = 2.30; <jats:italic>p<\/jats:italic> = 0.02), and visual analogue scale (VAS) pain (MD = \u221214.01, 95% CI [\u221216.16, \u221211.85]; <jats:italic>Z<\/jats:italic> = 12.74; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.00001). The studies that are methodically reviewed also discover heterogeneity, which may have resulted from the created pooled data and requires more analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients with OA, <jats:sc>l<\/jats:sc>\u2010carnitine effectively decreases clinical signs and symptoms, inflammatory markers, pain, and stiffness indicators, and significantly improves WOMAC and VAS scores.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202300614","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T05:11:09Z","timestamp":1708665069000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of <scp>l<\/scp>\u2010Carnitine Supplementation on Osteoarthritis: A Systematic Review"],"prefix":"10.1002","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6321-3925","authenticated-orcid":false,"given":"Haiyang","family":"Kou","sequence":"first","affiliation":[{"name":"Department of Joint Surgery Translational Medicine Center Honghui Hospital Xi'an Jiaotong University  Xi'an Shaanxi 710000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy First School of Clinical Medicine Shaanxi University of Traditional Chinese Medicine  Xianyang Shaanxi 712046 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhili","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy First School of Clinical Medicine Shaanxi University of Traditional Chinese Medicine  Xianyang Shaanxi 712046 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbing","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Joint Surgery Translational Medicine Center Honghui Hospital Xi'an Jiaotong University  Xi'an Shaanxi 710000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,22]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMct1215534"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp051726"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2019.10.007"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-15-1792-1_15"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2018.11.001"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","unstructured":"R. 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