{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T03:58:05Z","timestamp":1788667085455,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T00:00:00Z","timestamp":1708128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32001676"],"award-info":[{"award-number":["32001676"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Iron status is regulated via iron absorption as there is no active iron excretion. Divalent metal\u2010ion transporter\u20101 (DMT1) and ferroportin (FPN) are two key proteins vital for iron absorption, but the regulation of them in suckling mammals differs from that in adults. This study aims to explore regulation of iron transporters under different iron conditions during suckling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>This study developed suckling rats under different iron conditions. Unexpectedly, unchanged FPN at different iron status are detected. Since FPN is the only known iron exporter for mammals, unchanged FPN limits iron exported into blood during suckling. Thus, factors regulating FPN at transcriptional, post\u2010transcriptional, and post\u2010translational levels are detected. Results showed that <jats:italic>Fpn<\/jats:italic> mRNA is upregulated, while micro RNA\u2010485(miR\u2010485) which could silence <jats:italic>Fpn<\/jats:italic> mRNA is upregulated at low iron status limiting translation of <jats:italic>Fpn<\/jats:italic> mRNA. Besides, serum hepcidin and liver <jats:italic>Hamp<\/jats:italic> mRNA are upregulated, but ring finger protein 217(\u00a0<jats:italic>Rnf217<\/jats:italic>) mRNA remained unchanged at high iron status leading to FPN not downregulated as adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overall, this study indicates that translational regulation limits intestinal FPN protein response to iron deficiency and <jats:italic>Rnf217<\/jats:italic> cannot effectively mediate the degradation of FPN at high iron status, which provides a reference for maintaining iron homeostasis during suckling.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202300617","type":"journal-article","created":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T11:39:55Z","timestamp":1708169995000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Intracellular Regulation Limits the Response of Intestinal Ferroportin to Iron Status in Suckling Rats"],"prefix":"10.1002","volume":"68","author":[{"given":"Lili","family":"Qiu","sequence":"first","affiliation":[{"name":"College of Food Science &amp; Nutritional Engineering China Agricultural University  Beijing 100083 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxiao","family":"Hu","sequence":"additional","affiliation":[{"name":"College of Food Science &amp; Nutritional Engineering China Agricultural University  Beijing 100083 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiyu","family":"Qin","sequence":"additional","affiliation":[{"name":"College of Food Science &amp; Nutritional Engineering China Agricultural University  Beijing 100083 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Song","sequence":"additional","affiliation":[{"name":"College of Food Science &amp; Nutritional Engineering China Agricultural University  Beijing 100083 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory of Precision Nutrition and Food Quality Department of Nutrition and Health China Agricultural University  Beijing 100193 China"},{"name":"Food Laboratory of Zhongyuan  Luohe 462300 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0242-8943","authenticated-orcid":false,"given":"Xiaoyu","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Food Science &amp; Nutritional Engineering China Agricultural University  Beijing 100083 China"},{"name":"Key Laboratory of Precision Nutrition and Food Quality Department of Nutrition and Health China Agricultural University  Beijing 100193 China"},{"name":"Food Laboratory of Zhongyuan  Luohe 462300 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,17]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.02.028"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23105341"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.116.013896"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000481447"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114519002496"},{"key":"e_1_2_10_6_1","first-page":"1","volume":"25","author":"Valverde\u2010Bruffau V. J.","year":"2021","journal-title":"Public Health Nutr."},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxy227"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9040338"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-071812-161215"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/41343"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/35001596"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2016.12.002"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.vh.2019.01.002"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/78.6.1203"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000243791"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2668-z"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqaa174"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26001"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(03)00408-2"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.09.006"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2009.03.006"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003408"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-015-1362-3"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8101135"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00107.2003"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/78.6.1203"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxz172"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14153176"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxy111"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2011.11.069"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1504891112"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.020123"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.03.007"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg392"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1854-0"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-03-0672"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020008986"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuac066"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.151043"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308083100"}],"container-title":["Molecular Nutrition &amp; Food Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.202300617","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T08:52:37Z","timestamp":1712134357000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mnfr.202300617"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,17]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/mnfr.202300617"],"URL":"https:\/\/doi.org\/10.1002\/mnfr.202300617","archive":["Portico"],"relation":{},"ISSN":["1613-4125","1613-4133"],"issn-type":[{"value":"1613-4125","type":"print"},{"value":"1613-4133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,17]]},"assertion":[{"value":"2023-08-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2300617"}}