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High\u2010fat diet (HFD)\u2010induced obesity is closely related to the disease severity of psoriasis, but the mechanism is not fully understood.<\/jats:p><jats:p>Methods and results: The study utilizes the HFD\u2010induced obesity model along with an imiquimod (IMQ)\u2010induced psoriasis\u2010like mouse model (HFD\u2010IMQ) to conduct transcriptomics and metabolomic analyses. HFD\u2010induced obese mice exhibits more severe psoriasis\u2010like lesions compared to normal diet (ND)\u2010IMQ mice. The expression of genes of the IL\u201017 signaling pathway (<jats:italic>IL\u201017A, IL\u201017F, S100A9, CCL20, CXCL1<\/jats:italic>) is significantly upregulated, leading to an accumulation of T cells and neutrophils in the skin. Moreover, the study finds that there is an inhibition of the branched\u2010chain amino acids (BCAAs) catabolism pathway, and the key gene branched\u2010chain amino transferase 2 (Bcat2) is significantly downregulated, and the levels of leucine, isoleucine, and valine are elevated in the HFD\u2010IMQ mice. Furthermore, the study finds that the peroxisome proliferator\u2010activated receptor gamma (PPAR \u03b3) is inhibited, while STAT3 activity is promoted in HFD\u2010IMQ mice.<\/jats:p><jats:p>Conclusion: HFD\u2010induced obesity significantly amplifies IL\u201017 signaling and exacerbates psoriasis, with a potential role played by Bcat2\u2010mediated BCAAs metabolism. The study suggests that BCAA catabolism and PPAR \u03b3\u2010STAT3 exacerbate inflammation in psoriasis with obesity.<\/jats:p>","DOI":"10.1002\/mnfr.202300720","type":"journal-article","created":{"date-parts":[[2024,4,6]],"date-time":"2024-04-06T11:54:14Z","timestamp":1712404454000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Bcat2\u2010Mediated Branched\u2010Chain Amino Acid Catabolism Is Linked to the Aggravated Inflammation in Obese with Psoriasis Mice"],"prefix":"10.1002","volume":"68","author":[{"given":"Yazhuo","family":"Wang","sequence":"first","affiliation":[{"name":"Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Institute of Traditional Chinese Medicine Beijing Key Laboratory of Clinic and Basic Research with Traditional Chinese Medicine on Psoriasis  Beijing 100010 China"},{"name":"Capital Medical University  Beijing 100069 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Traditional Chinese Medicine, Capital Medical University, Beijing Institute of Traditional Chinese Medicine Beijing Key Laboratory of Clinic and Basic Research with Traditional Chinese Medicine on Psoriasis  Beijing 100010 China"},{"name":"Beijing University of Chinese Medicine  Beijing 100029 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Qi","sequence":"additional","affiliation":[{"name":"Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Institute of Traditional Chinese Medicine Beijing Key Laboratory of Clinic and Basic Research with Traditional Chinese Medicine on Psoriasis  Beijing 100010 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqing","family":"Hu","sequence":"additional","affiliation":[{"name":"Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Institute of Traditional Chinese Medicine Beijing Key Laboratory of Clinic and Basic Research 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