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Lipid metabolism and its unbalance can also contribute to acute and chronic inflammation in different conditions. In celiac disease (CD), the serum phospholipid profile in infants who developed CD is dramatically different when compared to that of infants at risk of CD not developing the disease. In a mouse model of gluten sensitivity, oral wheat gliadin challenge in connection with inhibition of the metabolism of arachidonic acid, an omega\u20106 polyunsaturated fatty acid, specifically induces the enteropathy. Recent evidence suggests that gluten may play a role also for development of life\u2010style related diseases in populations on a high fat diet (HFD). However, the mechanisms behind these effects are not yet understood. Exploratory studies in mice feed HFD show that wheat gliadin consumption affects glucose and lipid metabolic homeostasis, alters the gut microbiota, and the immune cell profile in liver.<\/jats:p>","DOI":"10.1002\/mnfr.202300779","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T01:03:24Z","timestamp":1713402204000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["High Fat Diet\u2013Wheat Gliadin Interaction and its Implication for Obesity and Celiac Disease Onset: In Vivo Studies"],"prefix":"10.1002","volume":"68","author":[{"given":"Yuri","family":"Haneishi","sequence":"first","affiliation":[{"name":"Department of Applied Biological Science Graduate School of Agriculture Tokyo University of Agriculture and Technology  Fuchu\u2010shi Tokyo 183\u20138509 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Treppiccione","sequence":"additional","affiliation":[{"name":"Institute of Food Sciences, CNR  via Roma 64 Avellino 83100 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Maurano","sequence":"additional","affiliation":[{"name":"Institute of Food Sciences, CNR  via Roma 64 Avellino 83100 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diomira","family":"Luongo","sequence":"additional","affiliation":[{"name":"Institute of Food Sciences, CNR  via Roma 64 Avellino 83100 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6994-1787","authenticated-orcid":false,"given":"Junki","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Applied Biological Science Graduate School of Agriculture Tokyo University of Agriculture and Technology  Fuchu\u2010shi Tokyo 183\u20138509 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8631-1683","authenticated-orcid":false,"given":"Mauro","family":"Rossi","sequence":"additional","affiliation":[{"name":"Institute of Food Sciences, CNR  via Roma 64 Avellino 83100 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,17]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1987.tb36206.x"},{"key":"e_1_2_8_2_1","first-page":"S2","author":"Golay A.","year":"1997","journal-title":"Int. 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