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TGF\u2010\u03b2 is a multifunctional polypeptide molecule that acts as a pro\u2010fibrogenic marker, inflammatory cytokine, immunosuppressive agent, and pro\u2010carcinogenic growth factor during the progression of HCC. The preclinical and clinical evidence illustrates that TGF\u2010\u03b2 can induce epithelial\u2010to\u2010mesenchymal transition, promoting progression and hepatocyte immune evasion. Therefore, targeting the TGF\u2010\u03b2 pathway can be a promising therapeutic option against HCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>We carry out a systemic analysis of eight potentially selected culinary Indian spices: Turmeric, Black pepper, Ginger, Garlic, Fenugreek, Red pepper, Clove, Cinnamon, and their bioactives in regulation of the TGF\u2010\u03b2 pathway against liver cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Turmeric and its active constituent, curcumin, possess the highest therapeutic potential in treating inflammation\u2010induced HCC and they also have the maximum number of ongoing in\u2010vivo and in\u2010vitro studies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202300793","type":"journal-article","created":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T09:04:07Z","timestamp":1716195847000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Role of Culinary Indian Spices in the Regulation of TGF\u2010\u03b2 Signaling Pathway in Inflammation\u2010Induced Liver Cancer"],"prefix":"10.1002","volume":"68","author":[{"given":"Ajay Sarija","family":"Asoka","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy Amrita School of Pharmacy Amrita Vishwa Vidyapeetham AIMS Health Science Campus Ponekkara, P.O. 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