{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:02:36Z","timestamp":1753869756116,"version":"3.41.2"},"reference-count":42,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003970","name":"Isfahan University of Medical Sciences","doi-asserted-by":"publisher","award":["3400356"],"award-info":[{"award-number":["3400356"]}],"id":[{"id":"10.13039\/501100003970","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>The present study aims to assess the interaction of dietary patterns (DPs) and paraoxonase1 (PON1) rs662 polymorphism on coronary artery disease (CAD) severity and its risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>This cross\u2010sectional study is conducted on 425 patients undergoing angiography. The PON1 genotypes are detected by the polymerase chain reaction\u2010restriction fragment length polymorphism (RFLP\u2010PCR) technique. DPs are extracted by exploratory factor analysis. Two dietary patterns Western (WDP) and Traditional (TDP) are extracted. A gene\u2010diet interaction concerning a high Gensini score is observed. Accordingly, high adherence to the WDP increases the odds of a high Gensini score in R allele carriers compared to QQ genotype carriers by 2.48 times (odds ratio [OR]: 2.48, 95% confidence interval [CI] 0.98\u20136.26, <jats:italic>p<\/jats:italic> = 0.05). Also, the risk of high systolic blood pressure (SBP) is higher in R allele carriers with high adherence to the WDP compared to QQ genotype carriers\u00a0(OR: 3.49, 95% CI 1.38\u20138.82, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001. No significant interaction is observed between TDP and PON1 rs662 on any cardiometabolic risk factors (<jats:italic>p<\/jats:italic>\u2010value\u00a0&gt;\u00a00.05). The results remain significant after adjusting for confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present study's findings indicate the existence of an interaction between the <jats:italic>PON1<\/jats:italic> rs662 polymorphism and the WDP on the risk of stenosis severity and high SBP.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202300818","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T06:49:46Z","timestamp":1716446986000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Joint Effects of Dietary Patterns and <i>Paraoxonase1<\/i> rs662 Polymorphism on Coronary Artery Disease Severity (Gensini and SYNTAX Scores) and Its Risk Factors in adults Undergoing Angiography"],"prefix":"10.1002","volume":"68","author":[{"given":"Mina","family":"Darand","sequence":"first","affiliation":[{"name":"Prevention of Cardiovascular Disease Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2636-0963","authenticated-orcid":false,"given":"Gholamreza","family":"Askari","sequence":"additional","affiliation":[{"name":"Department of Community Nutrition School of Nutrition &amp; Food Sciences Isfahan University of Medical Sciences  Isfahan Iran"},{"name":"Nutrition and Food Security Research Center Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Awat","family":"Feizi","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology School of Health, and Clinical Toxicology Research Center and Cardiac Rehabilitation Research Center, Cardiovascular Research Institute Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyedmostafa","family":"Seyedhossaini","sequence":"additional","affiliation":[{"name":"Yazd Cardiovascular Research Center Noncommunicable Disease Research Institute Shahid Sadoughi University of Medical Science  Yazd Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamidreza","family":"Ashrafzadeh","sequence":"additional","affiliation":[{"name":"Abortion Research Center Yazd Reproductive Sciences Institute Shahid Sadoughi University of Medical Sciences  Yazd Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vahid","family":"Arabi","sequence":"additional","affiliation":[{"name":"Research Center for Food Hygiene and Safety, School of Public Health Shahid Sadoughi University of Medical Sciences  Yazd Iran"},{"name":"Department of Nutrition School of Public Health Shahid Sadoughi University of Medical Sciences  Yazd Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahdie","family":"Yavari","sequence":"additional","affiliation":[{"name":"Division of Genetics Department of Cell and Molecular Biology and Microbiology Faculty of Science and Biotechnology University of Isfahan  Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azam Ahmadi","family":"Vasmehjani","sequence":"additional","affiliation":[{"name":"Department of Nutrition School of Public Health Shahid Sadoughi University of Medical Sciences  Yazd Iran"},{"name":"Nutrition Improvement Group; Health Department Guilan University of Medical Sciences  Guilan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amin","family":"Salehi\u2010Abargouei","sequence":"additional","affiliation":[{"name":"Yazd Cardiovascular Research Center Noncommunicable Disease Research Institute Shahid Sadoughi University of Medical Science  Yazd Iran"},{"name":"Research Center for Food Hygiene and Safety, School of Public Health Shahid Sadoughi University of Medical Sciences  Yazd Iran"},{"name":"Department of Nutrition School of Public Health Shahid Sadoughi University of Medical Sciences  Yazd Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,22]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000558"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311849"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487315587402"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.28350"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000437740.48606.d1"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2018.06.877"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2016.10.008"},{"key":"e_1_2_10_8_1","first-page":"599","volume":"31","author":"Kuhail M.","year":"2021","journal-title":"Ethiop. 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