{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:56:47Z","timestamp":1790632607091,"version":"4.1.0"},"reference-count":62,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T00:00:00Z","timestamp":1717718400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2023JJ60306"],"award-info":[{"award-number":["2023JJ60306"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Diabetic liver injury (DLI) is one of the complications of diabetes mellitus, which seriously jeopardizes human health. Punicalagin (PU), a polyphenolic compound mainly found in pomegranate peel, has been shown to ameliorate metabolic diseases such as DLI, and the mechanism needs to be further explored. In this study, a HFD\/STZ\u2010induced diabetic mouse model is established to investigate the effect and mechanism of PU on DLI. The results show that PU intervention significantly improves liver histology and serum biochemical abnormalities in diabetic mice, significantly inhibits the expression of pyroptosis\u2010related proteins such as NLRP3, Caspase1, IL\u20101\u03b2, and GSDMD in the liver of diabetic mice, and up\u2010regulated the expression of autophagy\u2010related proteins. Meanwhile, PU treatment significantly increases FoxO1 protein expression and inhibits TXNIP protein expression in the liver of diabetic mice. The above results are further verified in the HepG2 cell injury model induced by high glucose. AS1842856 is a FoxO1 specific inhibitor. The intervention of AS1842856 combined with PU reverses the regulatory effects of PU on pyroptosis and autophagy in HepG2 cells. In conclusion, this study demonstrates that PU may inhibit pyroptosis and upregulate autophagy by regulating FoxO1\/TXNIP signaling, thereby alleviating DLI.<\/jats:p>","DOI":"10.1002\/mnfr.202300912","type":"journal-article","created":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T13:11:13Z","timestamp":1717765873000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Punicalagin Ameliorates Diabetic Liver Injury by Inhibiting Pyroptosis and Promoting Autophagy via Modulation of the FoxO1\/TXNIP Signaling Pathway"],"prefix":"10.1002","volume":"68","author":[{"given":"Xiuying","family":"Tan","sequence":"first","affiliation":[{"name":"Xiangya School of Public Health Central South University Changsha 410013 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Long","sequence":"additional","affiliation":[{"name":"Children's Medical Center People's Hospital Hunan Province Changsha 410005 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rou","family":"Zhang","sequence":"additional","affiliation":[{"name":"Xiangya School of Public Health Central South University Changsha 410013 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Xiangya School of Public Health Central South University Changsha 410013 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"You","sequence":"additional","affiliation":[{"name":"Xiangya School of Public Health Central South University Changsha 410013 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9503-3344","authenticated-orcid":false,"given":"Lina","family":"Yang","sequence":"additional","affiliation":[{"name":"Xiangya School of Public Health Central South University Changsha 410013 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,7]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2021.109119"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2018.10.004"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.06.021"},{"key":"e_1_2_10_4_1","first-page":"599","volume":"18","author":"Targher G.","year":"2021","journal-title":"Nat. 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