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This study aims to investigate the impact of postbiotics on ameliorating alcohol\u2010induced hepatic steatosis and the underlying mechanisms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      Using network pharmacology, the study elucidates the targets and pathways impacted by postbiotics from\n                      <jats:italic>L. reuteri<\/jats:italic>\n                      , identifying the farnesoid X receptor (FXR) as a promising target for postbiotics against ALD, and lipid metabolism and alcoholism act as crucial pathways associated with postbiotics\u2010targeting ALD. Furthermore, the study conducts histological and biochemical analyses coupled with LC\/MS to evaluate the protective effects and mechanisms of postbiotics against ALD. Postbiotics may modulate bile acid metabolism in vivo by regulating FXR signaling, activating the FXR\/FGF15 pathway, and influencing the enterohepatic circulation of bile acids (BAs). Subsequently, postbiotics regulate hepatic FXR activated by BAs and modulate the expression of FXR\u2010mediated protein, including short regulatory partner (SHP)\u00a0and sterol regulatory element binding protein\u20101c (SREBP\u20101c), thereby ameliorating hepatic steatosis in mice with ALD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Postbiotics effectively alleviate ethanol\u2010induced hepatic steatosis by regulating the FXR\/SHP\/SREBP\u20101c axis, as rigorously validated in both in vivo and in vitro.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mnfr.202300927","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T23:50:24Z","timestamp":1719532224000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Postbiotics Prepared 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