{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:55:33Z","timestamp":1791608133859,"version":"4.3.4"},"reference-count":19,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T00:00:00Z","timestamp":1719964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Celiac disease (CD) is an allergic intestinal disease caused mainly by gliadin in wheat, which is widespread in the population and currently lacks effective treatment. \u03b1\u2010Gliadin peptides cause cellular damage by substantially increasing cellular reactive oxygen species (ROS) levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>This study investigates the protective effect of 11 pea\u2010derived peptides (PPs) on \u0251\u2010gliadin peptide (P31\u201043) treated Caco\u20102 cells. Results show that cells treated with PP2, PP5, and PP6 peptides significantly reduce the cell mortality caused by P31\u201043. Three PPs significantly reduce the P31\u201043\u2010induced decrease in ROS levels to control levels, and there is no difference between them and the vitamin C (Vc) group. The results in terms of antioxidant\u2010related enzymes show that PPs significantly decrease superoxide dismutase activity (SOD), glutathione reductases (GR), and glutathione (GSH)\/oxidized glutathione (GSSG) levels, thus significantly enhancing the antioxidant level of cells. By studying the key proteins of the Kelch\u2010like ECH\u2010associated protein 1 (Keap1)\/NF\u2010E2\u2010related factor 2 (Nrf2) pathway, it is found that PPs activate the Keap1\/Nrf2 signaling pathway.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study finds that peptides from peas can effectively alleviate \u0251\u2010gliadin peptide\u2010induced cell damage. The discovery of these food\u2010derived peptides provides novel potential solutions for the prevention and treatment of CD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202400010","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T10:10:25Z","timestamp":1720001425000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["In Vitro Protective Effect of Pea\u2010Derived Peptides (PPs) via the Keap1\/Nrf2 Signaling Pathway on Alpha\u2010Gliadin\u2010Sensitizing Peptide Induced Cacao\u20102 Cells"],"prefix":"10.1002","volume":"68","author":[{"given":"Bing","family":"Gao","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Zhengzhou University  1# Mianfang Street Zhengzhou 450052 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4880-131X","authenticated-orcid":false,"given":"Chenxu","family":"Cui","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Animal Immunology Henan Academy of Agricultural Sciences  116# Huayuan Road Zhengzhou Henan Province 450002 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Yan","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Zhengzhou University  1# Mianfang Street Zhengzhou 450052 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[{"name":"School of Food Science and Technology Henan Agricultural University  63#Agricultural Road Zhengzhou 450000 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Sun","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Animal Immunology Henan Academy of Agricultural Sciences  116# Huayuan Road Zhengzhou Henan Province 450002 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4791-5916","authenticated-orcid":false,"given":"Fangyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Animal Immunology Henan Academy of Agricultural Sciences  116# Huayuan Road Zhengzhou Henan Province 450002 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunfeng","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Zhengzhou University  1# Mianfang Street Zhengzhou 450052 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,3]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu4040243"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.136366"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.169656"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-19-4552"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R900010200"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.2000.1824"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.1926"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201000021"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf102538g"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2013.06.095"},{"key":"e_1_2_9_11_1","unstructured":"Q.Zhang Y.Tian Nat. 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