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Plasma SHBG levels are altered in metabolic disorders such as obesity, anorexia, and insulin resistance. Several reports have shown that diets in terms of total calories or fat, fiber, or protein content can alter plasma SHBG levels. However, there are many components in a diet that can affect <jats:italic>SHBG<\/jats:italic> gene expression in the liver. In order to unravel the molecular mechanisms by which diets regulate SHBG production, it would be necessary to analyze single diet components and\/or nutritional factors. This review summarizes the recent advances in identifying different nutritional factors regulating SHBG production and the related molecular mechanism, as well as the clinical implications.<\/jats:p>","DOI":"10.1002\/mnfr.202400020","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T10:47:48Z","timestamp":1719485268000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Recent Advances on Sex Hormone\u2010Binding Globulin Regulation by Nutritional Factors: Clinical Implications"],"prefix":"10.1002","volume":"68","author":[{"given":"Laura","family":"Brianso\u2010Llort","sequence":"first","affiliation":[{"name":"Diabetes and Metabolism Research Unit Vall Hebron Institut de Recerca (VHIR), Universitat Aut\u00f2noma de Barcelona and Biomedical Network Research Centre on Diabetes and Metabolic Diseases (CIBERDEM, ISCIII)  Barcelona 08035 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Sa\u00e9z\u2010Lopez","sequence":"additional","affiliation":[{"name":"Diabetes and Metabolism Research Unit Vall Hebron Institut de Recerca (VHIR), Universitat Aut\u00f2noma de Barcelona and Biomedical Network Research Centre on Diabetes and Metabolic Diseases (CIBERDEM, ISCIII)  Barcelona 08035 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Alvarez\u2010Guaita","sequence":"additional","affiliation":[{"name":"Diabetes and Metabolism Research Unit Vall Hebron Institut de Recerca (VHIR), Universitat Aut\u00f2noma de Barcelona and Biomedical Network Research Centre on Diabetes and Metabolic Diseases (CIBERDEM, ISCIII)  Barcelona 08035 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Ramos\u2010Perez","sequence":"additional","affiliation":[{"name":"Diabetes and Metabolism Research Unit Vall Hebron Institut de Recerca (VHIR), Universitat Aut\u00f2noma de Barcelona and Biomedical Network Research Centre on Diabetes and Metabolic Diseases (CIBERDEM, ISCIII)  Barcelona 08035 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Diabetes and Metabolism Research Unit Vall Hebron Institut de Recerca (VHIR), Universitat Aut\u00f2noma de Barcelona and Biomedical Network Research Centre on Diabetes and Metabolic Diseases (CIBERDEM, ISCIII)  Barcelona 08035 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Sim\u00f3","sequence":"additional","affiliation":[{"name":"Diabetes and Metabolism Research Unit Vall Hebron Institut de Recerca (VHIR), Universitat Aut\u00f2noma de Barcelona and Biomedical Network Research Centre on Diabetes and Metabolic Diseases (CIBERDEM, ISCIII)  Barcelona 08035 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0333-5629","authenticated-orcid":false,"given":"David M.","family":"Selva","sequence":"additional","affiliation":[{"name":"Diabetes and Metabolism Research Unit Vall Hebron Institut de Recerca (VHIR), Universitat Aut\u00f2noma de Barcelona and Biomedical Network Research Centre on Diabetes and Metabolic Diseases (CIBERDEM, ISCIII)  Barcelona 08035 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,27]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.111.092593"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.51.34105"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-12509-x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M409616200"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","unstructured":"P. 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