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The study aims to explore the association between 25\u2010hydroxyvitamin D [25(OH)D] and gut mycobiota and to investigate the link between the identified mycobial features and blood glycemic traits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>The study examines the association between serum 25(OH)D levels and the gut mycobiota in the Westlake Precision Birth Cohort, which includes pregnant women with gestational diabetes mellitus (GDM). The study develops a genetic risk score (GRS) for 25(OH)D to validate the observational results. In both the prospective and cross\u2010sectional analyses, the vitamin D is associated with gut mycobiota diversity. Specifically, the abundance of <jats:italic>Saccharomyces<\/jats:italic> is significantly lower in the vitamin D\u2010sufficient group than in the vitamin D\u2010deficient group. The GRS of 25(OH)D is inversely associated with the abundance of <jats:italic>Saccharomyces<\/jats:italic>. Moreover, the <jats:italic>Saccharomyces<\/jats:italic> is positively associated with blood glucose levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Blood vitamin D status is associated with the diversity and composition of gut mycobiota in women with GDM, which may provide new insights into the mechanistic understanding of the relationship between vitamin D levels and metabolic health.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202400022","type":"journal-article","created":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T02:48:59Z","timestamp":1716173339000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cross\u2010Sectional and Prospective Association of Serum 25\u2010Hydroxyvitamin D with Gut Mycobiota during Pregnancy among Women with Gestational 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