{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T00:13:47Z","timestamp":1794442427258,"version":"4.9.1"},"reference-count":65,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2024,6,23]],"date-time":"2024-06-23T00:00:00Z","timestamp":1719100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>High blood pressure (BP) is the main preventable risk factor for cardiovascular diseases (CVDs). Much research is aimed at finding natural alternatives to control or prevent hypertension (HT), since some hypertensive patients do not respond to current pharmacological treatments or show undesirable side effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Forty relevant articles have been selected from various scientific literature databases. The results reveal that angiotensin\u2010converting enzyme (ACE) inhibition is the most reported mechanism of action of antihypertensive peptides. The active peptides have a great variety of origins. Biopeptides with a molecular weight of &lt;3 kDa, short chain &lt;20 amino acids, and a hydrophobic amino acid sequence at the C\u2010 and N\u2010terminus exhibit higher antihypertensive activity. They also show good stability to enzymatic hydrolysis and gastrointestinal digestion, and no toxicity. To determine antihypertensive effectiveness, in vitro and in vivo animal studies are the most frequent developed, with few in silico studies and only one human clinical trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There is interesting potential for antihypertensive peptides as promising natural candidates for the development of functional foods, nutraceuticals and drugs for preventive or therapeutic treatment of hypertension. The aim of this review is to study the role of food\u2010derived bioactive peptides in HT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202400084","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T06:41:30Z","timestamp":1719211290000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Potential Impact of Bioactive Peptides from Foods in the Treatment of Hypertension"],"prefix":"10.1002","volume":"68","author":[{"given":"Natalia","family":"Ichim","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology\u2010A University of Murcia  Murcia 30071 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Mar\u00edn","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Cl\u00ednico Universitario Virgen de la Arrixaca  Murcia 30120 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